The National Institutes of Health (NIH) is preparing to release a Notice of Funding Opportunity (NOFO) for research applications focused on developing behavioral interventions for individuals living with Alzheimer's disease and related dementias, as well as their caregivers. This initiative aims to support a milestone-driven planning phase lasting up to two years, with the potential for transition to a clinical trial phase upon successful completion of the required milestones. The funding opportunity is particularly significant as it addresses critical health challenges associated with aging and dementia care. Interested small businesses are encouraged to prepare for this opportunity, with the estimated synopsis posting date set for November 1, 2025, and applications expected to close by February 16, 2026. For further inquiries, potential applicants can contact Dr. Melissa Riddle at melissa-riddle@nih.gov or by phone at 301-480-6761.