Advancing Research on Empirically-Supported Interventions for Older Adults Living with Serious Mental Illness (SMI)
ID: 359201Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Small Businesses

Funding Category

Health

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes
Timeline
    Description

    The National Institutes of Health (NIH) is set to release a Notice of Funding Opportunity (NOFO) aimed at advancing research on empirically-supported interventions for older adults living with serious mental illness (SMI). This initiative seeks to optimize, deliver, and sustain effective mental health interventions tailored for this demographic, encouraging multidisciplinary collaboration to enhance care transitions and improve access to evidence-based treatments. With an estimated total program funding of $3 million and the expectation of awarding five grants, interested small businesses should prepare to submit their applications following the anticipated synopsis posting on August 15, 2025, with a closing date of October 15, 2025. For further inquiries, potential applicants can contact the National Institute of Mental Health at NIMHinitiatives@mail.nih.gov.

    Point(s) of Contact
    National Institute of Mental Health (NIMH)
    TBA
    NIMHinitiatives@mail.nih.gov
    Files
    No associated files provided.
    Similar Opportunities
    Dementia Care and Caregiver Support Intervention Research - Stages II - V
    National Institutes of Health
    The National Institutes of Health (NIH) is preparing to release a Notice of Funding Opportunity (NOFO) for research applications focused on developing behavioral interventions for individuals living with Alzheimer's disease and related dementias, as well as their caregivers. This initiative aims to support a milestone-driven planning phase lasting up to two years, with the potential for transition to a clinical trial phase upon successful completion of the required milestones. The funding opportunity is particularly significant as it addresses critical health challenges associated with aging and dementia care. Interested small businesses are encouraged to prepare for this opportunity, with the estimated synopsis posting date set for November 1, 2025, and applications expected to close by February 16, 2026. For further inquiries, potential applicants can contact Dr. Melissa Riddle at melissa-riddle@nih.gov or by phone at 301-480-6761.
    NIMH Biobehavioral Research Awards for Innovative New Scientists (NIMH BRAINS) (R01 Clinical Trial Optional)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering the NIMH Biobehavioral Research Awards for Innovative New Scientists (NIMH BRAINS), a federal grant aimed at supporting early-career scientists in advancing their research in mental health. This initiative seeks to foster innovative clinical, translational, or basic research that can significantly enhance the understanding, diagnosis, treatment, or prevention of mental health disorders. With an estimated total program funding of $3 million and the expectation of awarding six grants, this opportunity is designed for small businesses committed to impactful research in the field. Interested applicants can reach out to Dr. Eric R. Murphy at eric.murphy@nih.gov or by phone at 301-443-9230 for further information, with the anticipated synopsis posting date on September 20, 2025, and a closing date of October 20, 2025.
    Early- and Late-Stage Clinical Trials for the Spectrum of Alzheimer's Disease/Alzheimer's Disease-Related Dementias and Age-Related Cognitive Decline
    National Institutes of Health
    The National Institutes of Health (NIH) is preparing to publish a Notice of Funding Opportunity (NOFO) aimed at supporting early- and late-stage clinical trials focused on Alzheimer's Disease (AD), Alzheimer's Disease-Related Dementias (ADRD), and age-related cognitive decline. This initiative seeks applications that propose innovative pharmacological and non-pharmacological interventions to address cognitive, behavioral, and neuropsychiatric changes associated with these conditions, as well as studies to enhance trial design and methodologies. The funding opportunity, categorized under health-related discretionary grants, is intended for small businesses with expertise in aging research, with an estimated synopsis posting date of August 1, 2025, and a closing date for applications expected by October 5, 2025. For further inquiries, interested applicants can contact Laurie Ryan, Ph.D., at 301-496-9350 or via email at ryanl@mail.nih.gov.
    Research Opportunities in Crisis Response Services for Suicide Prevention
    National Institutes of Health
    The National Institutes of Health (NIH) is set to announce a funding opportunity for research focused on crisis response services aimed at suicide prevention. This initiative seeks to examine the effectiveness and implementation of crisis response practices, with an emphasis on improving the quality and outcomes of interventions in real-world settings, while considering various psychosocial factors and health disparities. The total estimated funding for this program is $2 million, with approximately five awards expected to be granted. Interested applicants, particularly small businesses with expertise in crisis response and suicide prevention, are encouraged to prepare for this opportunity, with the anticipated synopsis posting date on September 8, 2025, and a closing date for applications on October 8, 2025. For further inquiries, potential applicants can contact Dr. Jennifer Humensky at jennifer.humensky@nih.gov or by phone at 301-480-1265.
    Dementia Care and Caregiver Support Intervention Research - Stage I Only
    National Institutes of Health
    The National Institutes of Health (NIH) is set to announce a funding opportunity titled "Dementia Care and Caregiver Support Intervention Research - Stage I Only," aimed at supporting research focused on developing behavioral interventions for individuals living with Alzheimer's disease and related dementias, as well as their caregivers. This initiative will utilize the R34 activity code and is designed to facilitate the development, modification, and refinement of principle-based behavioral interventions, ensuring their acceptability and feasibility in preparation for later-stage clinical trials. Interested small businesses are encouraged to begin forming collaborations and developing project proposals, with the estimated synopsis posting date on November 1, 2025, and a closing date for applications expected by February 16, 2026. For further inquiries, potential applicants can contact Melissa Riddle, Ph.D., at melissa-riddle@nih.gov or by phone at 301-480-6761.
    Mind and Body Interventions to Restore Whole Person Health via Emotional Well-Being Mechanisms
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a grant opportunity titled "Mind and Body Interventions to Restore Whole Person Health via Emotional Well-Being Mechanisms." This initiative aims to fund research that investigates how various mind and body interventions, such as mindfulness meditation, yoga, and acupuncture, can enhance whole person health through mechanisms of emotional well-being. The program emphasizes the importance of understanding the biological mechanisms behind these interventions and their potential to improve health outcomes, addressing significant gaps in current research. The estimated total funding for this program is $2 million, with three awards expected to be granted. Interested applicants, particularly small businesses, can reach out to Erin Burke Quinlan, Ph.D., at erin.quinlan@nih.gov or by phone at 301-480-9483 for further information. The application process is set to open on October 14, 2025, with a closing date of December 15, 2025, and anticipated award announcements by July 1, 2026.
    Addressing Methodological Challenges with Clinical Trials of Psychotomimetic Agents
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a grant opportunity titled "Addressing Methodological Challenges with Clinical Trials of Psychotomimetic Agents," aimed at soliciting research applications that tackle the methodological issues associated with clinical trials involving psychotomimetic agents (PMAs). The focus of this initiative is to enhance the understanding of the therapeutic effects of PMAs, such as psilocybin and MDMA, which have shown potential benefits for mental health disorders like depression and anxiety, thereby increasing confidence in clinical trial outcomes. The estimated total program funding is $5 million, with approximately five awards anticipated, and interested applicants are encouraged to engage with the FDA prior to submission to ensure compliance with regulatory requirements. For further inquiries, potential applicants can contact Jonathan Sabbagh, Ph.D., at jonathan.sabbagh@nih.gov or by phone at 301-793-3534. The synopsis is expected to be posted on September 3, 2025, with applications closing on November 3, 2025, and awards anticipated by July 1, 2026.
    Assessing the Feasibility of Incorporating Mechanisms in Multisite Clinical Trials of Mind and Body Interventions on Whole Person Health Restoration (R01 Clinical Trial Required)
    National Institutes of Health
    The National Institutes of Health (NIH) is preparing to release a Notice of Funding Opportunity (NOFO) aimed at supporting multi-site feasibility studies of mind and body interventions, such as meditation and yoga, to enhance whole person health restoration. The objective of this funding opportunity is to establish foundational work that will inform future large-scale clinical trials, focusing on the effectiveness of these interventions and their impact on emotional well-being. This initiative is particularly significant as it seeks to enhance the generalizability and reproducibility of findings through studies conducted across multiple geographically distinct sites. Interested applicants, particularly multidisciplinary teams with expertise in complementary health and clinical trial design, should prepare for the anticipated NOFO, which will utilize the R01 Clinical Trial Required activity code. For further inquiries, potential applicants can contact Dr. Jennifer N. Baumgartner at jennifer.baumgartner@nih.gov or by phone at 301-402-4084. The estimated synopsis post date is December 5, 2025, with a closing date expected on February 5, 2026, and project start date anticipated for July 1, 2026.
    Pilot Effectiveness Trials of Peer Support Services for Suicide Prevention
    National Institutes of Health
    The National Institutes of Health (NIH) is announcing a funding opportunity titled "Pilot Effectiveness Trials of Peer Support Services for Suicide Prevention," aimed at soliciting research applications focused on the preliminary effectiveness of peer support interventions in reducing suicide risk. The initiative seeks to evaluate the feasibility, acceptability, and potential effectiveness of these interventions in clinical and community settings, while also gathering preliminary data necessary for larger-scale trials. This grant, categorized under health funding activities, has an estimated total program funding of $3 million and is open to small businesses with relevant expertise. Interested applicants should note that applications are not currently being solicited, but they are encouraged to prepare collaborative projects ahead of the estimated synopsis posting on August 28, 2025, with a closing date for submissions anticipated on October 28, 2025. For further inquiries, potential applicants can contact Stephen O'Connor, Ph.D., at stephen.oconnor@nih.gov or by phone at 301-480-8366.
    NeuroNEXT Small Business Innovation in Clinical Trials (U44 Clinical Trial Optional)
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a funding opportunity titled "NeuroNEXT Small Business Innovation in Clinical Trials," aimed at encouraging small businesses to conduct exploratory clinical trials of investigational agents related to neurological disorders. This initiative seeks applications for Phase II Small Business Innovation Research (SBIR) projects, with a budget of up to $3 million over five years, focusing on trials that align with the strategic plan of the National Institute of Neurological Disorders and Stroke (NINDS). The program is designed to foster public-private partnerships to enhance the development and commercialization of innovative therapies, ultimately improving clinical outcomes in neuroscience research. Interested applicants must adhere to a Community Engagement and Research Inclusion (CERI) plan, with the first application deadline set for January 5, 2025, and additional deadlines throughout 2026 and 2027. For further inquiries, applicants can contact NIH Grants Information at grantsinfo@nih.gov.