The National Institutes of Health (NIH) is set to release a Notice of Funding Opportunity (NOFO) aimed at advancing research on empirically-supported interventions for older adults living with serious mental illness (SMI). This initiative seeks to optimize, deliver, and sustain effective mental health interventions tailored for this demographic, encouraging multidisciplinary collaboration to enhance care transitions and improve access to evidence-based treatments. With an estimated total program funding of $3 million and the expectation of awarding five grants, interested small businesses should prepare to submit their applications following the anticipated synopsis posting on August 15, 2025, with a closing date of October 15, 2025. For further inquiries, potential applicants can contact the National Institute of Mental Health at NIMHinitiatives@mail.nih.gov.