The Department of Health and Human Services (NIH) is announcing a funding opportunity (PAR-26-116) to support collaborative translational research at the NIH Clinical Center. This program, a reissue of PAR-21-343, aims to bridge basic biological discoveries with clinical applications to improve health outcomes. It encourages partnerships between NIH intramural and extramural investigators, providing extramural researchers access to the Clinical Center's unique resources. Applications must include at least one intramural scientist as a co-PD/PI, and a significant portion of the clinical research must be conducted at the NIH Clinical Center. The maximum award is $500,000 direct costs annually for up to four years, with a potential fifth planning year. Eligibility extends to various organizations, including higher education, non-profits, for-profits, and government entities, including foreign organizations. Applications must include a Collaboration Plan and letters of support from the NIH Clinical Center and a participating NIH Institute/Center. Non-responsive applications include those making minimal use of Clinical Center resources, such as relying solely on banked samples or data. Key dates for application submission are in February and March of 2026 and 2027, with an open date of January 5, 2026, and an expiration date of March 6, 2027.