The National Institutes of Health (NIH) is inviting applications for a cooperative agreement aimed at developing optimal treatment strategies for the use of anti-obesity medications (AOMs) in children and adolescents. This initiative seeks clinical centers to join a consortium focused on testing AOM treatment strategies that maximize benefits while minimizing risks, emphasizing healthy growth, nutritional intake, and mental well-being. The project is critical in addressing obesity in youth, with a focus on determining the best developmental stages for AOM initiation and evaluating predictors of treatment response. Interested applicants can reach out to Dr. Stavroula K. Osganian at (301) 827-6939 or via email at voula.osganian@nih.gov. The estimated award date is July 1, 2027, with applications due by December 1, 2026, and a total of three awards expected.