The National Institutes of Health (NIH) is offering a funding opportunity through the Chemical Countermeasures Research Program (CCRP) Initiative, aimed at supporting basic research on the deleterious effects of acute exposure to Ultra-Potent Synthetic (UPS) opioids, such as fentanyl and carfentanil. This initiative seeks to identify and validate mechanisms, signaling pathways, and therapeutic targets to understand and mitigate the effects of UPS opioid overdose and its associated toxicities, including potential long-term health consequences. The program emphasizes interdisciplinary studies focusing on biological and molecular pathways involved in opioid toxicity, with a total funding amount of $2.5 million available for up to six awards. Interested applicants must submit their proposals by November 19, 2024, and can find additional information and submission guidelines at the NIH grants website or contact NIH Grants Information at grantsinfo@nih.gov.