The National Institutes of Health (NIH) is offering a funding opportunity under the HEAL Initiative, titled "Translating Research to Practice to End the Overdose Crisis (R61/R33 Clinical Trial Optional)." This grant aims to support action-oriented research that translates evidence-based practices into effective care systems for individuals facing addiction, with a focus on reducing overdose deaths through stigma-free, patient-centered approaches and outreach to underserved populations. The initiative is critical for enhancing the quality and accessibility of addiction care, emphasizing innovative strategies and stakeholder collaboration aligned with the HHS Overdose Prevention Strategy. Interested applicants can apply for funding up to $750,000, with a total anticipated funding of up to $15 million for related projects, and must submit their applications by March 20, 2025. For further inquiries, contact the NIH OER Webmaster at OERWebmaster03@od.nih.gov or visit the full announcement at http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-23-053.html.