TECHNOLOGY LICENSING OPPORTUNITY: Thermostable GlowTag (YFAST)
Type: Special Notice
Overview

Buyer

ENERGY, DEPARTMENT OFENERGY, DEPARTMENT OFTRIAD - DOE CONTRACTORColumbus, OH, 43201, USA

NAICS

Research and Development in Biotechnology (except Nanobiotechnology) (541714)

PSC

DRUGS AND BIOLOGICALS (6505)

Set Aside

No Set aside used (NONE)

Original Source

https://sam.gov/workspace/contract/opp/ab9e2c311b9f4ecba1ffa5621975d81e/view
Timeline
    Description

    The Department of Energy is offering a technology licensing opportunity for the Thermostable GlowTag (YFAST), developed by scientists at the Los Alamos National Laboratory. This innovative technology addresses the challenges in enzyme engineering by providing a high-throughput screening platform that utilizes a modified fluorogenic protein, tsFAST, which glows when correctly folded and remains stable at elevated temperatures. The application of this technology is significant across various industries, including biofuels, waste management, and chemical manufacturing, as it enables the engineering of mesophilic enzymes for heat resistance and improves screening accuracy while reducing operational costs. Interested parties can reach out to Caleb Ledgerwood or Lindsay Augustyn at licensing@lanl.gov for further details, with the technology currently at TRL 2-3 and a U.S. patent pending.

    Point(s) of Contact
    Caleb Ledgerwood
    licensing@lanl.gov
    Lindsay Augustyn
    licensing@lanl.gov
    Files
    Title
    Posted
    FCI-tech-summary-visual-YFAST.jpg
    This document outlines a technology licensing opportunity for Thermostable GlowTag (YFAST), a modified fluorescent protein developed using Parageobacillus thermoglucosidasius. YFAST glows when correctly folded and remains stable under high temperatures, offering significant advantages for rapid, high-throughput screening. It reduces false positives and allows for engineering mesophilic enzymes for heat resistance, ensuring enzyme stability without refrigeration. This innovation solves the problem of needing a thermostable fluorescent reporter that provides real-time signals and improves screening accuracy through direct selection. Market applications include biofuels, waste management, chemical and pharmaceutical manufacturing, food and beverage processing, and textiles and detergents. The technology is at TRL 2-3 with a US Patent pending.
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    TECHNOLOGY LICENSING OPPORTUNITY: Thermostable GlowTag (YFAST)
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