TECHNOLOGY/BUSINESS OPPORTUNITY Modified cyclodextrins to counteract the effects of fentanyl and related opioids
ID: IL-13067Type: Special Notice
Overview

Buyer

ENERGY, DEPARTMENT OFENERGY, DEPARTMENT OFLLNS – DOE CONTRACTORLivermore, CA, 94551, USA

NAICS

Pharmaceutical Preparation Manufacturing (325412)

Original Source

https://sam.gov/opp/a7b8aab4f05c4fd1a1137fbb0bbd25d8/view
Timeline
    Description

    The Department of Energy, through the Lawrence Livermore National Laboratory (LLNL), is offering a collaboration opportunity to further develop and commercialize modified cyclodextrins aimed at counteracting the effects of fentanyl and related opioids. This initiative seeks industry partners capable of advancing the technology, which has shown promise in binding to fentanyl and reducing its bioavailability, thereby providing a potential treatment for opioid overdoses. Given the escalating opioid epidemic, this technology represents a significant advancement in medical countermeasures, with applications in therapeutic settings, forensic research, and environmental remediation. Interested companies should submit a statement of interest, including relevant corporate expertise and contact information, to LLNL's Innovation and Partnerships Office by email or written correspondence.

    Point(s) of Contact
    Yash Vaishnav
    (925) 422-3538
    vaishnav1@llnl.gov
    Charlotte Eng
    (925) 422-1905
    eng23@llnl.gov
    Files
    No associated files provided.
    Similar Opportunities
    CAPABILITY: Magnetic Resonance Experiments
    Energy, Department Of
    The Department of Energy, specifically the Los Alamos National Laboratory (LANL), is offering a unique opportunity for companies interested in testing equipment for the detection of illicit substances, such as fentanyl, using magnetic resonance techniques. This initiative provides access to a controlled laboratory environment and relevant samples, along with support for experimental setup, handling of substances, and interpretation of results. The capability is part of LANL's broader effort to foster innovation and commercialize technologies developed by its researchers, with licensing options available for patented inventions and software. Interested parties can reach out to Kathleen McDonald at licensing@lanl.gov for further information.
    Catalysts with Tunable Electrocatalytic Behavior for CO₂ Conversion
    Energy, Department Of
    The Department of Energy, through the Battelle Energy Alliance at the Idaho National Laboratory, is seeking industry partners to license innovative catalysts with tunable electrocatalytic behavior for CO₂ conversion. The objective is to address significant challenges in current CO₂ electrochemical conversion systems, including low product selectivity, rigid system designs, and economic constraints, by introducing a supported-metal catalyst that allows for precise control over catalytic behavior and product output. This technology is particularly relevant for carbon-intensive industries and chemical manufacturing, enhancing the economic viability of carbon capture, utilization, and storage initiatives. Interested parties can reach out to the Technology Deployment department at td@inl.gov for collaboration opportunities, as the focus is on licensing intellectual property rather than procurement or hiring services.
    Efficient Additive Manufacturing for Advanced U-X Nuclear Fuel Alloys
    Energy, Department Of
    The Department of Energy, through the Battelle Energy Alliance at the Idaho National Laboratory, is seeking industry partners to license innovative technology for efficient additive manufacturing of advanced U-X nuclear fuel alloys. The objective is to revolutionize the production of U-X compounds, such as U3Si2 and U-Mo alloys, by utilizing a patented Laser Engineered Net Shaping (LENS) process that streamlines manufacturing, reduces costs, and enhances safety compared to traditional methods. This technology is crucial for applications in commercial nuclear reactors, research reactors, and defense and space sectors, facilitating the production of next-generation accident-tolerant fuels. Interested companies should contact the Technology Deployment department at td@inl.gov for collaboration opportunities, as the focus is on licensing rather than procurement or hiring services.
    INL Innovation Spotlight Advanced Radiation Monitoring: Fieldable Long-Length Scintillating Fibers
    Energy, Department Of
    The Department of Energy, through the Battelle Energy Alliance at the Idaho National Laboratory (INL), is seeking innovative solutions for advanced radiation monitoring utilizing fieldable long-length scintillating fibers. The objective is to develop a technology that effectively detects and monitors radiation in challenging environments, such as nuclear repositories and medical irradiation facilities, by employing durable scintillating fibers exceeding 10 meters in length, combined with standard optical fibers over 100 meters. This technology addresses significant challenges in radiation monitoring, offering enhanced signal integrity and flexible deployment options essential for the safety and security of sensitive sites. Interested parties can contact Andrew Rankin at andrew.rankin@inl.gov for further information on licensing opportunities and collaboration, as this initiative is not a call for external services or funding.
    TECHNOLOGY LICENSING OPPORTUNITY: Thermostable GlowTag (YFAST)
    Energy, Department Of
    The Department of Energy is offering a technology licensing opportunity for the Thermostable GlowTag (YFAST), developed by scientists at the Los Alamos National Laboratory. This innovative technology addresses the challenges in enzyme engineering by providing a high-throughput screening platform that utilizes a modified fluorogenic protein, tsFAST, which glows when correctly folded and remains stable at elevated temperatures. The application of this technology is significant across various industries, including biofuels, waste management, and chemical manufacturing, as it enables the engineering of mesophilic enzymes for heat resistance and improves screening accuracy while reducing operational costs. Interested parties can reach out to Caleb Ledgerwood or Lindsay Augustyn at licensing@lanl.gov for further details, with the technology currently at TRL 2-3 and a U.S. patent pending.
    INL Innovation Spotlight Novel Training Surrogates for Emergency Response Training
    Energy, Department Of
    The Department of Energy, through the Battelle Energy Alliance at the Idaho National Laboratory (INL), is seeking innovative solutions for the development of novel training surrogates for emergency response training. The objective is to create short-lived radioisotopes that can effectively simulate the behavior and emissions of actual radioactive materials, thereby providing realistic training scenarios for emergency response personnel without the associated radiotoxicity risks. This initiative is crucial for enhancing the preparedness of military and emergency response teams, as it addresses the challenges of training with hazardous materials while ensuring safety and environmental considerations. Interested parties can contact Andrew Rankin at andrew.rankin@inl.gov for further information regarding licensing opportunities and collaboration, as this project is not a solicitation for external services or funding.
    Manufacturing Demonstration Facility: Technology Collaborations for US Manufacturers in Advanced Manufacturing and Materials Technologies
    Energy, Department Of
    The Department of Energy, through the Oak Ridge National Laboratory (ORNL), is seeking industry partners for collaborative projects aimed at developing energy-efficient manufacturing technologies within its Manufacturing Demonstration Facility (MDF). The initiative focuses on reducing manufacturing energy intensity and enhancing U.S. competitiveness by inviting proposals from industries engaged in material processing, particularly in advanced manufacturing technologies such as additive manufacturing and carbon fiber composites. Participants must provide at least a 50% cost share, and projects will be evaluated based on technical feasibility, potential for commercialization, and energy savings. Proposals can be submitted via email to MDFcollaboration@ornl.gov, and the submission period remains open, contingent on funding availability from the DOE Advanced Manufacturing Office.
    TECHNOLOGY LICENSING OPPORTUNITY: Remotely Operated Ultrasonic Separation (UltraSep)
    Energy, Department Of
    The Department of Energy is offering a technology licensing opportunity for UltraSep, a novel ultrasonic separation technology developed by Los Alamos National Laboratory. This technology aims to address inefficiencies in traditional filtration methods used in industrial manufacturing by providing a membrane-free solution that significantly reduces maintenance disruptions and operational footprint. UltraSep is designed for applications in various sectors, including food and beverage production, pharmaceutical processes, and critical nuclear operations, achieving over 99.9% metal removal and up to 95% bulk water extraction. Interested parties can reach out to Marc Witkowski or Lindsay Augustyn at licensing@lanl.gov for further discussions regarding partnership opportunities, as the technology is currently at Technology Readiness Level 5 and available for licensing agreements.
    Opportunity to collaborate using a Cooperative Research and Development Agreement (CRADA)
    Energy, Department Of
    The Department of Energy, through Sandia National Laboratories, is offering a collaboration opportunity via a Cooperative Research and Development Agreement (CRADA) for non-federal entities, including businesses, universities, and government agencies. This initiative aims to leverage Sandia's advanced technologies and expertise to enhance product development, academic research, and national security initiatives, fostering joint efforts that drive innovation and economic growth. Participants will have access to unique capabilities while jointly protecting any commercially valuable information produced during the partnership. Interested parties are encouraged to express their interest by contacting the CRADA team at CRADA@sandia.gov for further details on the collaboration process.
    Analgesic Ketamine for Battlefield Use
    Dept Of Defense
    The Department of Defense, through the Defense Health Agency (DHA), is conducting a Request for Information (RFI) for the development of an analgesic ketamine product intended for battlefield use. This initiative aims to identify industry partners capable of creating a solution for acute severe pain resulting from battlefield injuries, with a focus on products that are suitable for austere, pre-hospital conditions and do not require refrigeration or reconstitution. The desired ketamine formulations may include various delivery methods such as autoinjectors, oral capsules, and topical applications, and must be operable in extreme temperatures with a shelf life of 2-3 years. Interested parties are required to submit a Capabilities Statement by January 12, 2026, detailing their product characteristics, manufacturing capabilities, and FDA approval strategies. For further inquiries, contact Jeanette Collins at jeanette.m.collins4.civ@health.mil or Shannon Lertora at shannon.p.lertora.civ@health.mil.