ContractSpecial Notice

TECHNOLOGY LICENSING OPPORTUNITY: Thermostable GlowTag (YFAST)

DEPARTMENT OF ENERGY
Response Deadline
Jan 7, 2026
Deadline passed
Days Remaining
0
Closed
Set-Aside
No Set aside used
Notice Type
Special Notice

Contract Opportunity Analysis

The Department of Energy is offering a technology licensing opportunity for the Thermostable GlowTag (YFAST), developed by scientists at the Los Alamos National Laboratory. This innovative technology addresses the challenges in enzyme engineering by providing a high-throughput screening platform that utilizes a modified fluorogenic protein, tsFAST, which glows when correctly folded and remains stable at elevated temperatures. The application of this technology is significant across various industries, including biofuels, waste management, and chemical manufacturing, as it enables the engineering of mesophilic enzymes for heat resistance and improves screening accuracy while reducing operational costs. Interested parties can reach out to Caleb Ledgerwood or Lindsay Augustyn at licensing@lanl.gov for further details, with the technology currently at TRL 2-3 and a U.S. patent pending.

Classification Codes

NAICS Code
541714
Research and Development in Biotechnology (except Nanobiotechnology)
PSC Code
6505
DRUGS AND BIOLOGICALS

Solicitation Documents

1 Files
FCI-tech-summary-visual-YFAST.jpg
JPEG•198 KB•12/12/2025
AI Summary
This document outlines a technology licensing opportunity for Thermostable GlowTag (YFAST), a modified fluorescent protein developed using Parageobacillus thermoglucosidasius. YFAST glows when correctly folded and remains stable under high temperatures, offering significant advantages for rapid, high-throughput screening. It reduces false positives and allows for engineering mesophilic enzymes for heat resistance, ensuring enzyme stability without refrigeration. This innovation solves the problem of needing a thermostable fluorescent reporter that provides real-time signals and improves screening accuracy through direct selection. Market applications include biofuels, waste management, chemical and pharmaceutical manufacturing, food and beverage processing, and textiles and detergents. The technology is at TRL 2-3 with a US Patent pending.

Related Contract Opportunities

Project Timeline

postedOriginal Solicitation PostedDec 12, 2025
deadlineResponse DeadlineJan 7, 2026
expiryArchive DateJan 6, 2027

Agency Information

Department
DEPARTMENT OF ENERGY
Sub-Tier
ENERGY, DEPARTMENT OF
Office
TRIAD - DOE CONTRACTOR

Point of Contact

Name
Caleb Ledgerwood

Place of Performance

Los Alamos, New Mexico, UNITED STATES

Official Sources

View on SAM.gov