The Advanced Research Projects Agency for Health (ARPA-H) has announced the Innovative Solutions Opening (ISO) under solicitation number ARPA-H-SOL-24-104, inviting proposals for groundbreaking healthcare technologies. This solicitation aims to support innovative, disease-agnostic research projects that can significantly enhance health outcomes. Key interest areas include breakthrough technologies for maternal and fetal health, genetic and cellular therapies, and novel diagnostic tools. Eligible participants include universities, non-profits, and small businesses, with a deadline for submission set until March 3, 2029. Proposers must initially submit a solution summary for feedback before proceeding with full proposals, which will be evaluated based on scientific merit, relevance to ARPA-H’s mission, and proposer capabilities. The solicitation emphasizes transformative, high-impact solutions over incremental research and excludes proposals for traditional policy changes or infrastructure projects. Awards will primarily include Other Transactions and Cooperative Agreements, allowing for flexibility in negotiation without the constraints of Federal Acquisition Regulation. The process encourages innovative approaches that incorporate open standards and interoperability in healthcare technology.

The ARPA-H solicitation document outlines the requirements for submitting solution summaries in response to government Requests for Proposals (RFPs). It emphasizes the need for clarity and innovation in proposed technology concepts that address high-priority interest areas. Key sections include a Concept Summary where submitters detail their solutions and the problems they address, and Innovation and Impact, where the potential disruptiveness and superiority of the proposal over existing technologies should be demonstrated with measurable metrics. Additionally, the document specifies the Proposed Work section, where deliverables, milestones, and technical approaches must be clearly outlined alongside an analysis of technical challenges and risks. Team Organization and Capabilities highlight the roles of project members, supported by a Basis of Estimate (BOE) detailing financial requirements, work breakdown, and project costs. Submissions are restricted to six pages and must be formatted according to specified guidelines, ensuring readability and organization. This document serves to enhance the clarity and effectiveness of proposals within the context of federal funding opportunities, focusing on innovative solutions in healthcare and related fields.

The ARPA-H Health Science Futures Office has released an Innovative Solutions Opening (ISO) solicitation aimed at advancing revolutionary healthcare technologies through proposals that tackle significant health challenges. Eligible applicants, including universities and small businesses, are encouraged to submit solution summaries by March 3, 2025, before full proposals can be considered, and multiple awards are anticipated with a focus on innovative, disruptive solutions in biomedical research. The initiative emphasizes novel technologies that can address a wide range of diseases and improve health outcomes, while excluding projects that represent merely incremental advances.