Office-Wide Innovative Solutions Opening for Scalable Solutions Office (SSO)
ID: ARPA-H-SOL-24-105Type: Solicitation
Overview

Buyer

HEALTH AND HUMAN SERVICES, DEPARTMENT OFNATIONAL INSTITUTES OF HEALTHNIH ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH (ARPA-H)Bethesda, MD, 208920004, USA

NAICS

Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) (541715)

PSC

HEALTH R&D SERVICES; HEALTH CARE SERVICES; EXPERIMENTAL DEVELOPMENT (AN13)
Timeline
    Description

    The Department of Health and Human Services, through the National Institutes of Health's Advanced Research Projects Agency for Health (ARPA-H), is soliciting innovative solutions aimed at enhancing healthcare accessibility, affordability, and scalability. This opportunity invites universities, non-profits, small businesses, and similar entities to submit solution summaries and proposals that address health disparities, improve the distribution of healthcare technologies, and advance biomanufacturing innovations. The solicitation emphasizes the development of scalable technologies and collaborative distribution networks, with a focus on interdisciplinary approaches to revolutionize biomedicine and public health outcomes. Interested parties must submit their solution summaries by March 3, 2029, and can find further details and submission guidelines at https://solutions.arpa-h.gov. For inquiries, questions should be directed to the same website.

    Point(s) of Contact
    Files
    Title
    Posted
    The document outlines the guidelines for submissions in response to the ARPA-H-SOL-24-105 RFP Amendment 01. It serves as a template for interested parties to present innovative solutions addressing Health Security Framework (HSF) interest areas. Requirements include a cover letter detailing organization type, point of contact information, and a financial basis estimate. The core segments include a concept summary, focusing on innovative approaches to solve relevant problems, and an impact statement that outlines expected outcomes and disruptive potential compared to existing technologies. The document emphasizes the importance of detailing the final project deliverables, milestones, and key approaches, including potential risks and challenges. Team organization is highlighted, requiring a description of members' roles and expertise. Lastly, a comprehensive budget breakdown is required to ensure clarity in project costing. This document emphasizes structured, technical, and financial organization for successful grant proposals, ensuring that submissions align with federal guidelines and project objectives.
    The Advanced Research Projects Agency for Health (ARPA-H) is issuing a solicitation (ARPA-H-SOL-24-105) for innovative healthcare solutions to enhance accessibility, affordability, and scalability in health care delivery. The solicitation invites universities, non-profits, small businesses, and similar entities to submit solution summaries and proposals focused on addressing health disparities, improving the distribution of healthcare technologies, and advancing biomanufacturing innovations. Key areas of interest include scalable technologies adaptable to diverse contexts, collaborative distribution networks for efficient healthcare delivery, and advancements in biomanufacturing to reduce costs and enhance domestic competitiveness. Proposals should emphasize novel solutions that leverage interdisciplinary approaches while adhering to ARPA-H’s standards for intellectual property and compliance with relevant federal regulations. The solicitation is open until March 3, 2029, with multiple awards anticipated, and all submissions must undergo a mandatory solution summary review before full proposal submission. ARPA-H aims to stimulate high-impact health research that cannot be easily addressed through traditional means, highlighting its commitment to revolutionizing biomedicine and public health outcomes.
    The ARPA-H-SOL-24-104 Amendment 01 outlines a structured template for submissions related to innovative solutions fostering significant advancements in health science frameworks (HSF). Applicants must detail their proposals, including organization type, project description, innovation impact, technological approach, team organization, and a basis of estimate. Key sections focus on summarizing the project concept, identifying innovative outcomes, and outlining the technological novelty compared to current options. Milestones, deliverables, and potential challenges such as technical risks and mitigation strategies must also be included. Furthermore, the breakdown of project costs—covering labor, materials, travel, and profit—should be transparently detailed to facilitate evaluation. This document serves as a comprehensive guide for entities seeking federal grants or responding to RFPs, ensuring that proposals are both structured and aligned with overarching governmental health science objectives.
    The solicitation from the Advanced Research Projects Agency for Health (ARPA-H), titled "ARPA-H Scalable Solutions Office Innovative Solutions Opening," invites proposals aimed at enhancing healthcare access and affordability through innovative technologies and collaborative approaches. Eligible applicants include universities, non-profits, and businesses, with a focus on rapid deployment of scalable health solutions, particularly targeting underserved communities and specific health challenges. Proposals must undergo a review process, beginning with a solution summary submission, and will be evaluated based on their scientific merit, potential impact, and proposer capabilities, with multiple awards anticipated based on proposal quality and available funding.
    The ARPA-H Innovative Solutions Opening (ISO) solicitation seeks proposals for innovative projects aimed at improving the scalability and affordability of healthcare solutions while addressing disparities in access and quality of care. Eligible applicants include universities, non-profits, and businesses, and submissions require a preliminary solution summary before the full proposal, with submissions open until March 3, 2025. The solicitation emphasizes interdisciplinary approaches and novel methodologies to advance biomedicine and has specific exclusions for incremental advancements or proposals strictly related to policy or infrastructure development.
    Lifecycle
    Similar Opportunities
    Office-Wide Innovative Solutions Opening for Health Science Futures (HSF)
    Health And Human Services, Department Of
    The Department of Health and Human Services, through the National Institutes of Health's Advanced Research Projects Agency for Health (ARPA-H), is soliciting proposals for the Innovative Solutions Opening (ISO) aimed at advancing healthcare technologies. This initiative seeks innovative, disease-agnostic research projects that can significantly improve health outcomes, focusing on areas such as maternal and fetal health, genetic therapies, and novel diagnostic tools. The solicitation emphasizes the development of transformative solutions rather than incremental research, with submissions required to follow a two-step process: an initial solution summary followed by a full proposal based on feedback received. Interested parties must submit their solution summaries by March 3, 2029, via the designated ARPA-H portal, and are encouraged to review the detailed submission guidelines outlined in the provided documentation.
    Office-Wide Innovative Solutions Opening for Proactive Health Office (PHO)
    Health And Human Services, Department Of
    The Department of Health and Human Services, through the National Institutes of Health's Advanced Research Projects Agency for Health (ARPA-H), is soliciting innovative research proposals aimed at enhancing health outcomes via the Proactive Health Office (PHO). The initiative focuses on developing solutions that prioritize disease prevention, early intervention, and scalable wellness-promoting behaviors, moving away from traditional reactive healthcare models. This opportunity is significant for entities capable of delivering transformative health solutions, with proposals evaluated based on scientific merit and relevance, and funding potentially awarded through Other Transactions or Cooperative Agreements. Interested parties must submit a mandatory solution summary by March 3, 2029, and can direct inquiries to the designated contact via the provided submission platforms.
    Office-Wide Innovative Solutions Opening for Resilient Systems Office (RSO)
    Health And Human Services, Department Of
    The Department of Health and Human Services, through the National Institutes of Health's Advanced Research Projects Agency for Health (ARPA-H), is soliciting innovative solutions aimed at enhancing the resilience of healthcare systems via its Resilient Systems Office (RSO). This opportunity invites submissions from eligible entities, including universities, nonprofits, and small businesses, to address systemic challenges in healthcare and public health by leveraging cutting-edge technologies that improve care quality and availability. The solicitation emphasizes the importance of sociotechnical system innovations and adaptive solutions that enhance the reliability and interoperability of health ecosystems. Interested parties must submit solution summaries for feedback before full proposal submissions, with the solicitation open until March 3, 2029. For further inquiries, submissions should be directed to the designated online platforms, and the primary contact email is provided in the solicitation details.
    Emerging Health Innovators (EHI) Initiative
    Health And Human Services, Department Of
    The Department of Health and Human Services, through the National Institutes of Health's Advanced Research Projects Agency for Health (ARPA-H), is soliciting proposals for the Emerging Health Innovators (EHI) Initiative, aimed at fostering innovative biomedical solutions from early-career researchers and community-based organizations. This initiative invites submissions under two tracks: Technology-Driven Innovation and Community-Centered Innovation, with a focus on addressing significant gaps in health innovation and community health management. Proposals may seek funding up to $350,000 annually for a duration of two years, with a potential extension for a third year, and must adhere to strict compliance guidelines regarding research security, intellectual property, and human and animal subject research. Interested parties should contact the EHI Initiative Team at EHI@ARPA-H.gov, with proposals due by February 5, 2025, following a Proposers' Day on January 8, 2025.
    DRAFT Innovative Solutions Opening ARPA-H PROactive Solutions for Prolonging Resilience (PROSPR)
    Health And Human Services, Department Of
    The Department of Health and Human Services, through the National Institutes of Health's Advanced Research Projects Agency for Health (ARPA-H), is soliciting proposals for the DRAFT Innovative Solutions Opening (ISO) under the PROactive Solutions for Prolonging Resilience (PROSPR) program. This initiative aims to extend the healthspan of Americans by developing interventions that address the underlying causes of age-related health decline, including establishing a predictive Intrinsic Capacity score and repurposing FDA-approved drugs. The program emphasizes a structured, multidisciplinary approach over a five-year timeline, focusing on key milestones such as in-home assessment technologies and decentralized clinical trials to enhance accessibility in health interventions. Interested proposers can find more information and submit inquiries via the PROSPR email box at PROSPR@arpa-h.gov, with a final ISO expected to be published at a later date.
    Computational ADME Tox AnaLYsis for Safer Therapeutics (CATALYST) Innovative Solutions Opening
    Health And Human Services, Department Of
    The Department of Health and Human Services, through the National Institutes of Health's Advanced Research Projects Agency for Health (ARPA-H), is soliciting proposals for the Computational ADME Tox AnaLYsis for Safer Therapeutics (CATALYST) Innovative Solutions Opening. This initiative aims to develop innovative in silico human physiology modeling platforms that enhance drug safety assessments and reduce reliance on animal testing in preclinical studies, focusing on leveraging AI/ML for ADME-Tox simulations. The program is structured in two phases, with Phase I dedicated to developing predictive tools and Phase II aimed at integrating these tools into regulatory submissions for IND-enabling studies. Interested parties must submit a solution summary by November 25, 2024, and proposals by February 14, 2025, with all submissions made through the designated online platforms. For further inquiries, contact the CATALYST team via email at CATALYST@arpa-h.gov.
    ARPA-H ImagiNg Data EXchange (INDEX)
    Health And Human Services, Department Of
    The Department of Health and Human Services, through the National Institutes of Health's Advanced Research Projects Agency for Health (ARPA-H), is soliciting proposals for the Imaging Data Exchange (INDEX) program aimed at enhancing access to medical imaging data. The primary objective is to develop a sustainable platform that connects medical imaging data providers with researchers and developers, leveraging artificial intelligence and machine learning to address the shortage of qualified radiologists and improve healthcare outcomes. This initiative is critical for advancing algorithm development and clinical studies by creating a comprehensive repository of diverse imaging datasets, including cancer digital pathology and surgical videos. Interested parties must submit their Solution Summary by January 28, 2025, with the full proposal due by March 27, 2025. For further inquiries, contact the INDEX Team at INDEX@arpa-h.gov.
    Final Innovative Solutions Opening (ISO) ARPA-H Rare Disease AI/ML for Precision Integrated Diagnostics (RAPID)
    Health And Human Services, Department Of
    The Department of Health and Human Services, through the National Institutes of Health's Advanced Research Projects Agency for Health (ARPA-H), is soliciting proposals for the Final Innovative Solutions Opening (ISO) titled "Rare Disease AI/ML for Precision Integrated Diagnostics" (RAPID). This initiative aims to enhance the diagnostic process for rare diseases by developing advanced diagnostic support tools and optimizing health data collection, particularly for underdiagnosed populations. The RAPID program is critical for addressing the prolonged diagnostic challenges faced by millions of rare disease patients, with a focus on creating comprehensive datasets and fostering collaborations for real-world validation of diagnostic models. Interested applicants can reach out to the RAPID Email Box at RAPID@ARPA-H.gov for further information, with the program spanning a proposed 4.5-year timeline and emphasizing equitable access to diagnostics.
    ARPA-H Rare Disease AI/ML and Precision Integrated Diagnostics (RAPID) Patients’ Day
    Health And Human Services, Department Of
    The Department of Health and Human Services, through the National Institutes of Health's Advanced Research Projects Agency for Health (ARPA-H), is hosting a virtual event titled RAPID Patients’ Day on February 25, 2025, aimed at introducing the RAPID Program focused on utilizing artificial intelligence (AI) and machine learning (ML) for precision diagnostics in rare diseases. This event will provide insights into the ARPA-H mission, program goals, and the role of Patient Experience (PX) Partners, encouraging participation from patient advocacy groups to foster engagement and collaboration. The RAPID Program seeks to alleviate the diagnostic challenges faced by rare disease patients by developing innovative diagnostic tools and integrating comprehensive data, with registration for the event opening on December 19, 2024, and closing on February 21, 2025. Interested participants can reach out to the RAPID Email Box at RAPID@ARPA-H.gov for further information.
    ADVANCING CLINICAL TRIALS READINESS (ACTR)
    Health And Human Services, Department Of
    The Department of Health and Human Services, specifically the National Institutes of Health (NIH) through the Advanced Research Projects Agency for Health (ARPA-H), is hosting a hybrid Proposers’ Day for the Advancing Clinical Trials Readiness (ACTR) initiative. This event aims to gather insights and proposals that will enhance the readiness of clinical trials, focusing on innovative research and development in the health sector. The ACTR initiative is crucial for improving the efficiency and effectiveness of clinical trials, ultimately contributing to advancements in healthcare solutions. Interested parties can find registration details and additional information at the provided link, and inquiries can be directed to the ACTR Email Box at ACTR@ARPA-H.GOV.