PROactive Solutions for Prolonging Resilience (PROSPR)
ID: ARPA-H-SOL-25-125Type: Solicitation
Overview

Buyer

HEALTH AND HUMAN SERVICES, DEPARTMENT OFNATIONAL INSTITUTES OF HEALTHNIH ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH (ARPA-H)Bethesda, MD, 208920004, USA

NAICS

Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) (541715)

PSC

HEALTH R&D SERVICES; HEALTH CARE SERVICES; EXPERIMENTAL DEVELOPMENT (AN13)

Original Source

https://sam.gov/opp/96b1d19052874009a7165f4e0c21b110/view
Timeline
    Description

    The Department of Health and Human Services, through the National Institutes of Health's Advanced Research Projects Agency for Health (ARPA-H), is soliciting proposals for the PROactive Solutions for Prolonging Resilience (PROSPR) program. This initiative aims to extend the healthspan of Americans by developing interventions that address the underlying causes of age-related health decline, including the establishment of a predictive Intrinsic Capacity score and the repurposing of FDA-approved drugs. The program emphasizes a structured, multidisciplinary approach over a five-year timeline, focusing on key milestones such as in-home assessment technologies and decentralized clinical trials to create innovative preventative care models. Interested proposers are encouraged to reach out to the PROSPR Team at PROSPR@arpa-h.gov for inquiries, and further details can be found at the ARPA-H website. The final solicitation is anticipated to be published at a later date.

    Point(s) of Contact
    The PROSPR Team
    PROSPR@arpa-h.gov
    Files
    Title
    Posted
    25-SOL-125_DRAFT_PROSPR ISO.pdf
    The document outlines the ARPA-H solicitation for the PROactive Solutions for Prolonging Resilience (PROSPR) program, aimed at extending the healthspan of Americans by developing interventions that target the underlying causes of age-related health decline. The program includes establishing a predictive Intrinsic Capacity (IC) score, repurposing FDA-approved drugs, and testing second-generation interventions. The structured approach spans multiple technical areas over a five-year timeline, each with specific objectives, metrics, and phases, and engaging multidisciplinary teams to encourage collaboration. Key milestones include developing in-home assessment technologies, conducting decentralized clinical trials, and ensuring accessibility in health interventions. The program's ultimate goal is to create innovative preventative care models that reduce healthcare costs associated with chronic diseases while improving overall well-being for aging populations. Interested proposers are encouraged to attend a Proposers’ Day and submit questions via designated channels to promote participation and engagement.
    Similar Opportunities
    Office-Wide Innovative Solutions Opening for Proactive Health Office (PHO)
    Health And Human Services, Department Of
    The Department of Health and Human Services, through the National Institutes of Health's Advanced Research Projects Agency for Health (ARPA-H), is soliciting innovative research proposals aimed at enhancing health outcomes via the Proactive Health Office (PHO). The initiative focuses on developing solutions that prioritize disease prevention, early intervention, and scalable wellness-promoting behaviors, moving away from traditional reactive healthcare models. This opportunity is significant for entities capable of delivering transformative health solutions, with proposals evaluated based on scientific merit and relevance, and funding potentially awarded through Other Transactions or Cooperative Agreements. Interested parties must submit a mandatory solution summary by March 3, 2029, and can direct inquiries to the designated contact via the provided submission platforms.
    Office-Wide Innovative Solutions Opening for Health Science Futures (HSF)
    Health And Human Services, Department Of
    The Department of Health and Human Services, through the National Institutes of Health's Advanced Research Projects Agency for Health (ARPA-H), is soliciting proposals for the Innovative Solutions Opening (ISO) aimed at advancing healthcare technologies. This initiative seeks innovative, disease-agnostic research projects that can significantly improve health outcomes, focusing on areas such as maternal and fetal health, genetic therapies, and novel diagnostic tools. The solicitation emphasizes the development of transformative solutions rather than incremental research, with submissions required to follow a two-step process: an initial solution summary followed by a full proposal based on feedback received. Interested parties must submit their solution summaries by March 3, 2029, via the designated ARPA-H portal, and are encouraged to review the detailed submission guidelines outlined in the provided documentation.
    Office-Wide Innovative Solutions Opening for Resilient Systems Office (RSO)
    Health And Human Services, Department Of
    The Department of Health and Human Services, through the National Institutes of Health's Advanced Research Projects Agency for Health (ARPA-H), is soliciting innovative solutions aimed at enhancing the resilience of healthcare systems via its Resilient Systems Office (RSO). This opportunity invites submissions from eligible entities, including universities, nonprofits, and small businesses, to address systemic challenges in healthcare and public health by leveraging cutting-edge technologies that improve care quality and availability. The solicitation emphasizes the importance of sociotechnical system innovations and adaptive solutions that enhance the reliability and interoperability of health ecosystems. Interested parties must submit solution summaries for feedback before full proposal submissions, with the solicitation open until March 3, 2029. For further inquiries, submissions should be directed to the designated online platforms, and the primary contact email is provided in the solicitation details.
    Emerging Health Innovators (EHI) Initiative
    Health And Human Services, Department Of
    The Department of Health and Human Services, through the National Institutes of Health's Advanced Research Projects Agency for Health (ARPA-H), is soliciting proposals for the Emerging Health Innovators (EHI) Initiative, aimed at fostering innovative biomedical solutions from early-career researchers and community-based organizations. This initiative invites submissions under two tracks: Technology-Driven Innovation and Community-Centered Innovation, with a focus on addressing significant gaps in health innovation and community health management. Proposals may seek funding up to $350,000 annually for a duration of two years, with a potential extension for a third year, and must adhere to strict compliance guidelines regarding research security, intellectual property, and human and animal subject research. Interested parties should contact the EHI Initiative Team at EHI@ARPA-H.gov, with proposals due by February 5, 2025, following a Proposers' Day on January 8, 2025.
    Office-Wide Innovative Solutions Opening for Scalable Solutions Office (SSO)
    Health And Human Services, Department Of
    The Department of Health and Human Services, through the National Institutes of Health's Advanced Research Projects Agency for Health (ARPA-H), is soliciting innovative solutions aimed at enhancing healthcare accessibility, affordability, and scalability. This opportunity invites universities, non-profits, small businesses, and similar entities to submit solution summaries and proposals that address health disparities, improve the distribution of healthcare technologies, and advance biomanufacturing innovations. The solicitation emphasizes the development of scalable technologies and collaborative distribution networks, with a focus on interdisciplinary approaches to revolutionize biomedicine and public health outcomes. Interested parties must submit their solution summaries by March 3, 2029, and can find further details and submission guidelines at https://solutions.arpa-h.gov. For inquiries, questions should be directed to the same website.
    Computational ADME Tox AnaLYsis for Safer Therapeutics (CATALYST) Innovative Solutions Opening
    Health And Human Services, Department Of
    The Department of Health and Human Services, through the National Institutes of Health's Advanced Research Projects Agency for Health (ARPA-H), is soliciting proposals for the Computational ADME Tox AnaLYsis for Safer Therapeutics (CATALYST) Innovative Solutions Opening. This initiative aims to develop innovative in silico human physiology modeling platforms that enhance drug safety assessments and reduce reliance on animal testing in preclinical studies, focusing on leveraging AI/ML for ADME-Tox simulations. The program is structured in two phases, with Phase I dedicated to developing predictive tools and Phase II aimed at integrating these tools into regulatory submissions for IND-enabling studies. Interested parties must submit a solution summary by November 25, 2024, and proposals by February 14, 2025, with all submissions made through the designated online platforms. For further inquiries, contact the CATALYST team via email at CATALYST@arpa-h.gov.
    Final Innovative Solutions Opening (ISO) ARPA-H Rare Disease AI/ML for Precision Integrated Diagnostics (RAPID)
    Health And Human Services, Department Of
    The Department of Health and Human Services, through the National Institutes of Health's Advanced Research Projects Agency for Health (ARPA-H), is soliciting proposals for the Final Innovative Solutions Opening (ISO) titled "Rare Disease AI/ML for Precision Integrated Diagnostics" (RAPID). This initiative aims to enhance the diagnostic processes for rare diseases by developing advanced diagnostic support tools and optimizing large-scale health data collection, particularly focusing on underdiagnosed populations. The RAPID program is critical for addressing the prolonged diagnostic odysseys faced by millions of rare disease patients, with a structured approach that includes aggregating existing health data, collecting novel patient data, and creating a Rare Disease Data Commons for analytical evaluation. Interested parties can direct inquiries to the RAPID Email Box at RAPID@ARPA-H.gov, and should note that the program will operate over a proposed 4.5-year span, with specific milestones and evaluation criteria to ensure effective project execution.
    ARPA-H ImagiNg Data EXchange (INDEX)
    Health And Human Services, Department Of
    The Department of Health and Human Services, through the National Institutes of Health's Advanced Research Projects Agency for Health (ARPA-H), is soliciting proposals for the Imaging Data Exchange (INDEX) program aimed at enhancing access to medical imaging data. The primary objective is to develop a sustainable platform that connects medical imaging data providers with researchers and developers, leveraging artificial intelligence and machine learning to address the shortage of qualified radiologists and improve healthcare outcomes. This initiative is critical for advancing algorithm development and clinical studies by creating a comprehensive repository of diverse imaging datasets, including cancer digital pathology and surgical videos. Interested parties must submit their Solution Summary by January 28, 2025, with the full proposal due by March 27, 2025. For further inquiries, contact the INDEX Team at INDEX@arpa-h.gov.
    Ocular Laboratory for Analysis of Biomarkers (OCULAB)
    Health And Human Services, Department Of
    The Department of Health and Human Services, through the National Institutes of Health's Advanced Research Projects Agency for Health (ARPA-H), is soliciting proposals for the Ocular Laboratory for Analysis of Biomarkers (OCULAB) initiative. This program aims to develop innovative biosensor technologies for the continuous monitoring of tear biomarkers and AI-driven therapeutic delivery systems, particularly targeting conditions such as dry eye disease (DED). The initiative emphasizes collaboration among commercial entities and academic institutions to enhance diagnostic and treatment capabilities, ultimately striving to improve patient outcomes and healthcare accessibility. Interested parties should contact the OCULAB Team at OCULAB@ARPA-H.gov for further details, with multiple awards anticipated as part of this funding opportunity.
    BARDA DRIVe EZ-BAA (EZBAA - 22-100-SOL-00003)
    Health And Human Services, Department Of
    The Department of Health and Human Services, through the Biomedical Advanced Research and Development Authority (BARDA), is soliciting innovative research proposals under the Easy Broad Agency Announcement (EZ-BAA) BAA-22-100-SOL-00003, which is open until October 18, 2027. The initiative aims to address high-risk biomedical challenges related to public health emergencies, with specific Areas of Interest (AOIs) including drug repurposing, at-home diagnostics, and vaccine development. This program is crucial for enhancing the nation’s preparedness against emerging infectious diseases and other health threats, emphasizing the importance of innovative solutions in medical countermeasures. Interested parties must have active registration with SAM.gov and are encouraged to schedule pre-submission calls; key deadlines for abstract submissions vary by AOI, with multiple awards anticipated based on scientific merit and alignment with program goals.