The document outlines the ARPA-H solicitation for the PROactive Solutions for Prolonging Resilience (PROSPR) program, aimed at extending the healthspan of Americans by developing interventions that target the underlying causes of age-related health decline. The program includes establishing a predictive Intrinsic Capacity (IC) score, repurposing FDA-approved drugs, and testing second-generation interventions. The structured approach spans multiple technical areas over a five-year timeline, each with specific objectives, metrics, and phases, and engaging multidisciplinary teams to encourage collaboration. Key milestones include developing in-home assessment technologies, conducting decentralized clinical trials, and ensuring accessibility in health interventions. The program's ultimate goal is to create innovative preventative care models that reduce healthcare costs associated with chronic diseases while improving overall well-being for aging populations. Interested proposers are encouraged to attend a Proposers’ Day and submit questions via designated channels to promote participation and engagement.

The Advanced Research Projects Agency for Health (ARPA-H) has issued a final Innovative Solutions Opening (ISO) titled "PROactive Solutions for Preserving Resilience" (PROSPR). The program aims to extend the healthspan of Americans by developing preventative interventions targeting the underlying causes of age-related health decline. Proposals are sought from eligible entities to negotiate multiple Other Transaction Agreements (OTs). The solicitation covers detailed program information, eligibility, submission, evaluation processes, and general requirements for proposers. The PROSPR program has a five-year scope and focuses on three technical areas: 1) development of an intrinsic capacity score to evaluate health outcomes, 2) repurposing FDA-approved interventions, and 3) creating second-generation interventions. Each area includes defined phases for development, trials, and metrics to measure progress. The program aims to transform geriatric medicine into a preventive care model, emphasizing accessibility and health equity. With a variety of innovative deliverables and collaborative approaches, PROSPR seeks to tackle the significant economic burden of chronic diseases and enhance proactive health management for aging populations. Key deadlines for submission are set for April and May 2025, and interested proposers can find more information on the ARPA-H website.

The Advanced Research Projects Agency for Health (ARPA-H) launched the PROactive Solutions for Preserving Resilience (PROSPR) program through the Innovative Solutions Opening (ISO), aiming to extend Americans' healthspan by 20 years. This five-year initiative invites eligible applicants to propose interventions that focus on early disease prevention, targeting age-related health decline, which significantly affects healthcare costs. The program comprises three Technical Areas (TAs): 1. **TA1** focuses on developing a precise intrinsic capacity (IC) score to predict long-term health outcomes and creating an in-home assessment technology for continuous health monitoring. 2. **TA2** emphasizes the identification and repurposing of FDA-approved drugs to enhance healthspan, incorporating biomarkers from clinical trials to validate the effectiveness of these interventions. 3. **TA3** aims to test second-generation healthspan interventions through preclinical and first-in-human trials to evaluate safety and effectiveness. Proposers must ensure accessibility and inclusivity in their solutions, with a strong emphasis on regulatory compliance and collaboration across teams. The ISO timeline outlines key milestones, requiring participants to submit proposals by set deadlines and engage with regulatory bodies to establish innovative health interventions effectively.

The ARPA-H's Innovative Solutions Opening (ISO) seeks proposals for the PROactive Solutions for Preserving Resilience (PROSPR) program, aiming to enhance healthspan by addressing age-related health decline and chronic diseases. This initiative encourages collaborations among various entities to develop tools like an intrinsic capacity (IC) score that predicts long-term health outcomes based on physiological and biochemical indicators. The program is structured into three main Technical Areas (TAs): 1. **TA1** focuses on developing the PROSPR IC score and in-home assessment technology to facilitate proactive health management and lifestyle intervention studies. 2. **TA2** involves repurposing FDA-approved drugs to extend healthspan, identifying intervenable biomarkers, and conducting clinical trials to explore combined therapies. 3. **TA3** emphasizes the clinical testing of second-generation interventions demonstrated to maintain or improve health in preclinical models. The selected proposals will be evaluated based on scientific merit, the proposer's capabilities, and budget considerations. The overall objective is to transition into a preventive care model for aging populations, targeting systemic changes in health outcomes through innovative therapeutic strategies, ultimately reducing healthcare costs associated with aging-related diseases.

The ARPA-H Model Other Transaction Agreement pertains to the PROactive Solutions for Prolonging Resilience (PROSPR) program, which aims to develop interventions to extend healthspan by 20 years, addressing age-related health loss. The sample agreement outlines the terms and conditions for federal funding and project execution details, including project duration, management structure, deliverables, and financial obligations. Key components include the expectation for the Performer to manage the project, report milestones, and ensure compliance with regulations, particularly regarding human subjects and intellectual property rights. The agreement also details the Government's rights over inventions and data generated, emphasizing a collaborative approach while allowing flexibility for modifications. Lastly, the document emphasizes the importance of protecting intellectual property, especially regarding foreign access and security. This agreement serves as a framework for expedited negotiations for potential project awards, ensuring clarity in roles, responsibilities, and expected outcomes in advancing aging-related health interventions within a structured federal funding context.

The document outlines a federal government Request for Proposal (RFP) focused on cost proposal submissions by potential contractors. Its primary purpose is to guide proposers in developing, structuring, and providing thorough cost proposals that will be assessed by government officials during the evaluation process. Key elements include a detailed breakdown of projected costs, such as direct labor, general and administrative (G&A), subcontractors, consultants, and other direct costs. The document stresses the importance of justifying cost estimates and requires proposers to offer a clear explanation and evidence supporting their suggested expenses. Proposers must complete various tabs in the provided spreadsheet for different periods, including cost summaries for each task in the statement of work, ensuring that all expenses align with the total amounts submitted. Furthermore, the document emphasizes that all cost entries need to be precise and reconciled across worksheets to facilitate a streamlined evaluation and negotiation if selected for contract award. Important considerations such as fiscal year definitions and applicable labor categories are also outlined, highlighting the significance of adhering to federal guidelines and standards in proposal submissions. Overall, the document serves as a comprehensive guide enhancing transparency and consistency in the RFP process.