PROactive Solutions for Prolonging Resilience (PROSPR)
ID: ARPA-H-SOL-25-125Type: Solicitation
Overview

Buyer

HEALTH AND HUMAN SERVICES, DEPARTMENT OFNATIONAL INSTITUTES OF HEALTHNIH ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH (ARPA-H)Bethesda, MD, 208920004, USA

NAICS

Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) (541715)

PSC

HEALTH R&D SERVICES; HEALTH CARE SERVICES; EXPERIMENTAL DEVELOPMENT (AN13)

Original Source

https://sam.gov/opp/96b1d19052874009a7165f4e0c21b110/view
Timeline
    Description

    The Department of Health and Human Services, through the National Institutes of Health's Advanced Research Projects Agency for Health (ARPA-H), is soliciting proposals for the PROactive Solutions for Prolonging Resilience (PROSPR) program. This initiative aims to extend the healthspan of Americans by developing interventions that address the underlying causes of age-related health decline, including the establishment of a predictive Intrinsic Capacity score and the repurposing of FDA-approved drugs. The program emphasizes a structured, multidisciplinary approach over a five-year timeline, focusing on key milestones such as in-home assessment technologies and decentralized clinical trials to create innovative preventative care models. Interested proposers are encouraged to reach out to the PROSPR Team at PROSPR@arpa-h.gov for inquiries, and further details can be found at the ARPA-H website. The final solicitation is anticipated to be published at a later date.

    Point(s) of Contact
    The PROSPR Team
    PROSPR@arpa-h.gov
    Files
    Title
    Posted
    25-SOL-125_DRAFT_PROSPR ISO.pdf
    The document outlines the ARPA-H solicitation for the PROactive Solutions for Prolonging Resilience (PROSPR) program, aimed at extending the healthspan of Americans by developing interventions that target the underlying causes of age-related health decline. The program includes establishing a predictive Intrinsic Capacity (IC) score, repurposing FDA-approved drugs, and testing second-generation interventions. The structured approach spans multiple technical areas over a five-year timeline, each with specific objectives, metrics, and phases, and engaging multidisciplinary teams to encourage collaboration. Key milestones include developing in-home assessment technologies, conducting decentralized clinical trials, and ensuring accessibility in health interventions. The program's ultimate goal is to create innovative preventative care models that reduce healthcare costs associated with chronic diseases while improving overall well-being for aging populations. Interested proposers are encouraged to attend a Proposers’ Day and submit questions via designated channels to promote participation and engagement.
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