Presolicitation notice from the HEALTH AND HUMAN SERVICES, DEPARTMENT OF, NATIONAL INSTITUTES OF HEALTH, NIH ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH (ARPA-H) is seeking innovative solutions through individual Office-wide solicitations. The Office-wide ISOs will target specific areas of interest and may request abstracts and/or proposals. The goal is to select revolutionary ideas to improve health outcomes for all Americans. The solicitation will award Other Transactions and Cooperative Agreements, making the Federal Acquisition Regulations (FAR) not applicable. This notice includes DRAFT Office-wide ISOs for each ARPA-H Mission Office (HSF, PHO, RSO, and SSO). Questions regarding the DRAFT solicitations should be submitted through the provided link.