The Department of Energy is offering a technology licensing opportunity for the SmartBind pH Switch, an innovative advancement developed by scientists at Los Alamos National Laboratory. This technology significantly enhances the antibody purification process by utilizing a pH-switchable version of Protein G, allowing for gentle binding and release of antibodies without the damaging effects of harsh acidic conditions. The SmartBind pH Switch is particularly relevant for applications in biopharmaceuticals, life sciences research, and bioprocessing, providing improved stability, yield, and cost-effectiveness in antibody purification. Interested parties can reach out to Marc Witkowski or Lindsay Augustyn at licensing@lanl.gov for further discussions regarding licensing agreements, as this opportunity is not a call for external development services.