The Department of Health and Human Services, through the National Institutes of Health (NIH), intends to procure the Illumina, Inc NextSeq 2000 Sequencer Reagent Kit on a sole source basis. This procurement is essential for the Center for Cellular Engineering (CCE) to continue its ongoing studies involving bulk RNA-seq, TCR-seq, and single-cell DNA-seq, utilizing specific reagents that are only available from Illumina, Inc. The reagents are critical for maintaining the integrity and efficacy of clinical trials, and switching vendors would necessitate costly requalification processes that could delay patient treatments. Interested parties capable of providing similar products must submit a capability statement by May 23, 2025, to Emeka Onyejekwe at emeka.onyejekwe@nih.gov for consideration.