ARPA-H Rare Disease AI/ML and Precision Integrated Diagnostics (RAPID) Patients’ Day
ID: ARPA-H-SN-25-127Type: Special Notice
Overview

Buyer

HEALTH AND HUMAN SERVICES, DEPARTMENT OFNATIONAL INSTITUTES OF HEALTHNIH ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH (ARPA-H)Bethesda, MD, 208920004, USA

NAICS

Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) (541715)

PSC

HEALTH R&D SERVICES; HEALTH CARE SERVICES; EXPERIMENTAL DEVELOPMENT (AN13)
Timeline
    Description

    The Department of Health and Human Services, through the National Institutes of Health's Advanced Research Projects Agency for Health (ARPA-H), is hosting a virtual Patients’ Day on February 25, 2025, to introduce the RAPID Program, which focuses on utilizing artificial intelligence (AI) and machine learning (ML) for precision diagnostics in rare diseases. The event aims to provide insights into the ARPA-H mission, program goals, and the involvement of Patient Experience (PX) Partners, encouraging participation from patient advocacy groups to enhance the development of innovative diagnostic support tools and comprehensive data integration. This initiative is crucial for addressing the diagnostic challenges faced by rare disease patients, particularly in democratizing access to diagnostics for underserved communities. Registration for the event opens on December 19, 2024, and closes on February 21, 2025; interested parties can reach out to the RAPID Email Box at RAPID@ARPA-H.gov for further information.

    Point(s) of Contact
    RAPID Email Box
    RAPID@ARPA-H.gov
    Files
    Title
    Posted
    The Advanced Research Projects Agency for Health (ARPA-H) has announced a virtual Patients’ Day on February 25, 2025, aimed at introducing the RAPID Program, which focuses on employing AI and ML for precision diagnostic solutions in rare diseases. The event will provide insights about the ARPA-H mission, program goals, and the role of Patient Experience (PX) Partners, urging participation from patient advocacy groups. Registration for the event opens on December 19, 2024, and closes on February 21, 2025. The RAPID Program intends to end the diagnostic odyssey faced by rare disease patients by developing innovative diagnostic support tools and fostering comprehensive data integration. It will operate through several technical areas, including creating a massive rare disease dataset, leveraging novel diagnostic indicators, and developing a sustainable platform for AI diagnostic development. RAPID aims to democratize diagnostic access, ensuring benefits for underserved communities while promoting trust and engagement with patients throughout the research and diagnostic development process. This notice emphasizes participation in Patients’ Day as optional, with comprehensive details on PX Partner roles and program structure shared during the event.
    Similar Opportunities
    GENETIC MEDICINES AND INDIVIDUALIZED MANUFACTURING FOR EVERYONE (GIVE)
    Health And Human Services, Department Of
    The Department of Health and Human Services, through the Advanced Research Projects Agency for Health (ARPA-H), is soliciting proposals for the Genetic Medicines and Individualized Manufacturing for Everyone (GIVE) program. This initiative aims to revolutionize the biomanufacturing of RNA-based genetic medicines by fostering innovations in automated RNA manufacturing and integrated quality control, ultimately enabling rapid, cost-effective, and localized production in non-GMP environments. Interested parties must submit solution summaries by December 19, 2025, with full proposals due by February 27, 2026, and are encouraged to participate in a Proposers’ Day on November 13, 2025, for further insights. For additional information, please refer to the program's website or contact the designated email address.
    Proactive Health Office (PHO) Mission Office Innovative Solutions Opening (ISO)
    Health And Human Services, Department Of
    The Department of Health and Human Services, through the Advanced Research Projects Agency for Health (ARPA-H), is soliciting innovative solutions aimed at enhancing the healthspan and health outcomes of Americans by focusing on proactive health measures. The Proactive Health Office (PHO) seeks proposals that address population-level improvements in disease prevention, early detection methods, and system-level innovations for effective health delivery, emphasizing revolutionary advances rather than incremental improvements. This opportunity is critical for fostering advancements in public health and requires adherence to specific administrative and national policy guidelines, including intellectual property rights and research security measures. Interested parties must submit a Solution Summary by March 5, 2029, and can find further details and submission links at https://solutions.arpa-h.gov, with inquiries directed to the same site.
    Resilient Systems Office (RSO) Mission Office Innovative Solutions Opening (ISO)
    Health And Human Services, Department Of
    The Department of Health and Human Services, through the Advanced Research Projects Agency for Health (ARPA-H), is soliciting proposals for the Resilient Systems Office (RSO) Mission Office Innovative Solutions Opening (ISO). This opportunity invites submissions that address systemic challenges in healthcare and public health by leveraging innovative technologies to improve care quality, efficacy, and accessibility. Proposals will be evaluated based on scientific merit, alignment with ARPA-H's mission, proposer capabilities, and cost, with a focus on open-source intellectual property and compliance with research regulations. Interested parties must submit solution summaries and proposals via the designated ARPA-H portal, with the closing date for submissions set for March 5, 2029. For further inquiries, proposers can reach out through the same portal.
    Autonomous Interventions and Robotics (AIR) Advanced Research Projects Agency for Health (ARPA-H)
    Health And Human Services, Department Of
    The Department of Health and Human Services, through the Advanced Research Projects Agency for Health (ARPA-H), is seeking proposals for its Autonomous Interventions and Robotics (AIR) program, which aims to advance autonomous robotic surgery technologies. This initiative focuses on two technical areas: Autonomous Endovascular Robotics, which includes developing robotic systems for endovascular procedures and creating a simulation environment, and Microbots, which targets the development of untethered, autonomous microbots for various interventional procedures. The program is structured over a five-year timeline with specific phases and milestones, emphasizing collaboration with the FDA for regulatory approval. Interested parties are encouraged to attend a Proposers’ Day on December 16, 2025, in Washington, DC, to learn more about the program and network with potential collaborators. For further inquiries, contact the AIR Program at AIR@ARPA-H.GOV.
    Autonomous Interventions and Robotics (AIR) Advanced Research Projects Agency for Health (ARPA-H)
    Health And Human Services, Department Of
    The Department of Health and Human Services, through the Advanced Research Projects Agency for Health (ARPA-H), is soliciting proposals for the "Autonomous Interventions and Robotics (AIR)" program, aimed at advancing autonomous robotic surgery solutions. This initiative focuses on two technical areas: Autonomous Endovascular Robotics, which involves developing robotic systems for procedures such as thrombectomy and embolization, and Microbots, which seeks to create untethered surgical microbots for various interventional applications. The program spans five years, divided into a two-year Phase 1 and a three-year Phase 2, with eligibility open to universities, non-profits, and businesses, while excluding FFRDCs and government entities. Interested parties should note the revised deadlines for submissions: the Solution Summary is due by January 20, 2026, and the Full Proposal by March 18, 2026. For further inquiries, contact the AIR Program at AIR@ARPA-H.GOV.
    Independent Validation and Verification (IV&V) Services for the REACT Program
    Health And Human Services, Department Of
    The Department of Health and Human Services, through the Advanced Research Projects Agency for Health (ARPA-H), is seeking independent validation and verification (IV&V) services for its Resilient Extended Automatic Cell Therapies (REACT) program. The primary objective is to ensure the standardization and reproducibility of engineered cell lines used in developing wireless implantable medical devices, specifically the "Living Pharmacy" for therapeutic delivery and the "Living Sentinel" for disease tracking. These services are crucial for scaling manufacturing capabilities and aligning with regulatory standards, ultimately facilitating the commercialization of these health care devices. Proposals are due by January 5, 2026, with the contract covering a period from February 23, 2026, to August 22, 2028, and interested parties can contact Larin Harris at larim.harris@arpa-h.gov or Clare Sanchez at clare.sanchez@arpa-h.gov for further information.
    Special Notice for BioStabilization Systems (BoSS)
    Health And Human Services, Department Of
    The Department of Health and Human Services, through the Advanced Research Projects Agency for Health (ARPA-H), is hosting a Proposers’ Day for the BioStabilization Systems (BoSS) program on January 29, 2026. This initiative aims to revolutionize the storage and transport of biological medicines by developing innovative cell stabilization technologies that eliminate the need for ultra-cold conditions, and it seeks performer teams along with an Independent Verification and Validation (IV&V) partner. The BoSS program is critical for enhancing the accessibility and efficacy of biological medicines, and interested parties are encouraged to register for both in-person and virtual attendance, with registration deadlines in January 2026. For further details, including program specifics and registration information, potential proposers can refer to the BoSS Innovative Solutions Opening (ISO) available on SAM.gov and the attached Special Notice.
    Health Science Futures (HSF) Mission Office Innovative Solutions Opening (ISO)
    Health And Human Services, Department Of
    The Department of Health and Human Services, through the Advanced Research Projects Agency for Health (ARPA-H), is soliciting proposals for the Health Science Futures (HSF) Mission Office Innovative Solutions Opening (ISO). This initiative aims to gather innovative solutions that address future healthcare challenges, focusing on groundbreaking research in areas such as maternal/fetal medicine, genetic therapies, chronic diseases, and mental health, while excluding proposals for incremental advances or clinical trials. Proposers are required to submit a Solution Summary for initial feedback, followed by a detailed proposal that adheres to updated administrative and national policy requirements, including compliance with ethical research guidelines and research security disclosures. Interested parties should submit their proposals via the designated ARPA-H portal, with specific deadlines and further details available through the provided links.
    Scalable Solutions Office (SSO) Mission Office Innovative Solutions Opening (ISO)
    Health And Human Services, Department Of
    The Department of Health and Human Services, through the Advanced Research Projects Agency for Health (ARPA-H), is soliciting proposals for the Innovative Solutions Opening (ISO) under the Scalable Solutions Office (SSO). This initiative aims to develop innovative solutions that enhance healthcare access, affordability, and distribution, particularly in underserved communities, while addressing challenges in biomanufacturing and health technology distribution. The solicitation is open until March 5, 2029, and encourages submissions from academia, non-profits, and for-profit entities, with multiple awards anticipated as Other Transactions. Interested parties must submit a Solution Summary for initial feedback before proceeding with a full proposal, adhering to strict guidelines on intellectual property, research security, and cost proposal requirements. For further details, proposers can reach out through the designated submission portals and must ensure compliance with the updated administrative and national policy requirements outlined in the solicitation documents.
    Special Notice for BioStabilization Systems (BoSS)
    Health And Human Services, Department Of
    The Department of Health and Human Services, through the Advanced Research Projects Agency for Health (ARPA-H), is announcing a Special Notice for the BioStabilization Systems (BoSS) program, with a Proposers’ Day scheduled for January 29, 2026. This initiative aims to revolutionize the storage and transport of biological medicines by developing technologies that eliminate the need for ultra-cold conditions, and it seeks performer teams for breakthrough cell stabilization technologies and bioprocessing solutions, as well as an Independent Verification and Validation (IV&V) partner. The program is structured in three phases over four years, culminating in the transition of successful technologies to commercial partners, and encourages collaboration among teams. Interested parties can find more information and registration details on the ARPA-H website and should direct inquiries to the provided contact email, although it is noted that the email address should not be used for direct communication.