Reagents for Immunologic Analysis of Non-mammalian and Underrepresented Mammalian Models
ID: NIH/NIAID 129Type: BOTH
Overview

Topic

Reagents for Immunologic Analysis of Non-mammalian and Underrepresented Mammalian Models

Agency

Department of Health and Human ServicesNational Institutes of Health

Program

Type: SBIRPhase: BOTHYear: 2023

Topic Link

https://www.sbir.gov/node/2451735

Additional Information

https://sam.gov/opp/aa72581c848947f0b61c15062e604862/view
Timeline
  1. 1
    Release Aug 25, 2023 12:00 AM
  2. 2
    Open Aug 25, 2023 12:00 AM
  3. 3
    Next Submission Due Nov 14, 2023 12:00 AM
  4. 4
    Close Nov 14, 2023 12:00 AM
Description

The Department of Health and Human Services, specifically the National Institutes of Health (NIH), is seeking proposals for the development of reagents for immunologic analysis of non-mammalian and underrepresented mammalian models. The goal of this program is to address the limited availability of antibodies and immune receptor ligands for the identification and characterization of immune cells and responses in these models. Non-mammalian models of interest include amphibians, arthropods, fish, marine echinoids, and nematodes, while underrepresented mammalian models include bats, cats, cotton rats, dogs, ferrets, guinea pigs, hamsters, marmosets, minks, pigs, rabbits, and sheep.

The research topic focuses on the development of reagents that can be used to study basic immune defense pathways and mechanisms in these models. Non-mammalian models are particularly valuable for their tractability and adaptability to high-throughput screening formats. They also share conserved innate immune pathways with humans, making them useful for studying human pathogens. Underrepresented mammalian models, such as sheep and minks, have specific features that make them valuable for studying pregnancy, xenotransplantation, and zoonotic pathogen transmission.

The funding for this program is divided into two phases. Phase I provides $300,000 per year for up to 2 years, while Phase II provides $1,500,000 for up to 3 years. The program anticipates awarding 3-5 grants. Proposals that focus on targets for which no antibodies are available or for which commercially available reagents perform inadequately are encouraged. Proposals that include commercially available reagents as comparators for sub-optimal targets are also accepted.

For more information and to submit a proposal, interested parties can visit the SBIR topic link provided: link. The solicitation notice can be found on the agency's website: link. The application due date is November 14, 2023.

Files
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