The Department of Health and Human Services, specifically the National Institutes of Health, is seeking proposals for the development of novel tools and devices to improve animal welfare and support care of animal models in research facilities. The Office of Research Infrastructure Programs (ORIP) is particularly interested in applications from small business concerns (SBCs) for Small Business Innovation Research (SBIR) projects.
The goal of this solicitation is to address the issue of poor reproducibility in experiments that use animal models, which has negatively impacted biomedical research. The variation of intrinsic and extrinsic factors that can affect the physiological and biological response of animals has been identified as a source of irreproducibility. Therefore, there is a need for devices that can accurately monitor and control environmental conditions in animal facilities, such as temperature, humidity, vibrations, and ultrasonic noise.
Additionally, devices that can identify pathogens, allergens, and other pollutants in animal research environments are desired. Noninvasive or minimally invasive bio-logging devices for real-time monitoring of animal behavior, food/water consumption, and bodily functions are also needed. These devices should be discreet, robust, and easy to apply.
Furthermore, tools and devices that can ease the handling and restraining of animals, reduce stress, and improve the efficiency of animal-handling practices and experimental procedures are sought. Connecting diet, environmental conditions, and physiological measurements is also important for understanding the effects of extrinsic factors on experimental outcomes.
The solicitation emphasizes that innovation is crucial for designing useful tools and devices. The development and implementation of novel tools and devices, as well as the enhancement of existing equipment, are encouraged. Examples of specific areas of interest include portable software for managing and evaluating animal colonies, noninvasive technology for tracking and monitoring animals, automated feeding systems, devices for drug delivery and measurement, and improved systems for data collection and analysis.
The solicitation is open for applications, with multiple due dates throughout the year. The project duration and funding specifics can be found in the solicitation document available at the provided links. Applicants are advised to discuss their projects with the Scientific/Research contacts before submitting an application.