The Department of Health and Human Services, specifically the National Institutes of Health, is seeking proposals for the development and implementation of novel tools and devices to improve animal welfare and support animal model research. The goal is to enhance the management of individual animals and animal colonies, as well as improve the monitoring and control of environmental conditions that affect research outcomes and reproducibility. The variation in environmental conditions between different animal facilities has been identified as a source of irreproducibility in animal research. Therefore, the agency is looking for devices that can accurately monitor challenging environmental factors such as humidity, vibrations, odors, and ultrasonic noise. Additionally, there is a need for devices that can identify pathogens, allergens, and pollutants in animal research environments. Noninvasive or minimally invasive bio-logging devices for real-time monitoring of animal behavior and bodily functions are also desired. The agency emphasizes the importance of innovation and encourages the adaptation of technologies from other fields to improve animal research. The solicitation is open for Small Business Technology Transfer (STTR) projects, and the application due dates are on a rolling basis until September 6, 2024. For more information, interested parties can visit the SBIR topic link (https://www.sbir.gov/node/1972475) or the solicitation agency URL (https://grants.nih.gov/grants/guide/PA-files/PAR-21-226.html).