The National Institutes of Health (NIH) is planning to publish a Notice of Funding Opportunity (NOFO) for the "Advancing Non-Invasive Optical Approaches for Biological Systems" initiative, aimed at developing next-generation optical imaging techniques. This initiative seeks to address the challenges of light scattering in biological systems, enabling high-resolution imaging at greater depths within tissues, and will support three-year bi-phasic research projects through UG3/UH3 Cooperative Agreements. With an estimated total program funding of $4.9 million and an award ceiling of $1.6 million, the NIH anticipates issuing the NOFO in December 2024, with applications due by March 2025 and awards expected to be made by December 2025. Interested applicants are encouraged to prepare collaborative proposals in advance of the official announcement.