The National Institutes of Health (NIH) is issuing a funding opportunity to address health and healthcare disparities in non-communicable and chronic diseases in Latin America and among U.S. Hispanic/Latino populations. This initiative, titled "Interventions on Health and Healthcare Disparities on Non-Communicable and Chronic Diseases in Latin America," aims to support interdisciplinary research focused on clinical, health services, and community-based interventions. The goal is to identify and test strategies that improve understanding of social, behavioral, and clinical factors influencing minority health and reduce health disparities. Key objectives include optimizing intervention effectiveness, enhancing patient self-management, and expanding access to care, particularly in underserved communities. The funding opportunity is open for applications beginning February 5, 2025, and requires that collaborative research teams include members from both U.S. and Latin American institutions. Eligible applicants include higher education institutions, non-profits, and government entities, with a focus on innovative and impactful research designs, such as clinical trials. This funding emphasizes the need for responses to pressing health challenges faced by Hispanic/Latino populations, particularly regarding the high mortality and prevalence of NCDs. It encourages applicants to develop clearly defined interventions that can be implemented and evaluated within both community and healthcare settings throughout the region.