The National Institutes of Health (NIH) is inviting applications for the Pilot Health Services and Economic Research on the Treatment of Drug, Alcohol, and Tobacco Use Disorders (R34 - Clinical Trial Optional) funding opportunity. This initiative aims to support pilot and preliminary research that prepares for larger-scale effectiveness trials focused on optimizing access, quality, and affordability of treatment for substance use disorders, particularly through novel interventions or those lacking a robust evidence base. The funding opportunity provides a total of $450,000 over three years, with a maximum of $225,000 available in any single year, and applications are due by January 7, 2025. For further information, applicants can contact the NIH OER Webmaster at grantsinfo@nih.gov or visit the official announcement at http://grants.nih.gov/grants/guide/pa-files/PA-21-180.html.