The Centers for Disease Control and Prevention (CDC) has announced a Notice of Funding Opportunity (NOFO) aimed at enhancing surveillance and control of endemic and emerging arboviruses in Puerto Rico, particularly focusing on diseases such as dengue and Oropouche viruses. The initiative, coded RFA-CK-25-182, seeks to strengthen hospital and community-based research platforms, improve patient management, evaluate control strategies, and foster collaborations with local stakeholders. This funding opportunity is crucial for public health preparedness, aiming to reduce disease burden and optimize resource allocation within vulnerable communities. The total funding available is $25 million over five years, with a single award expected, and the application deadline is February 28, 2025. For more information, interested parties can contact Brian York at RYork@cdc.gov.