The NINDS Human Cell and Data Repository (U24 - Clinical Trial Not Allowed)
ID: 355092Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Cooperative Agreement

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes
Timeline
    Description

    The National Institutes of Health (NIH) is inviting applications for the NINDS Human Cell and Data Repository (NHCDR) through a cooperative agreement aimed at advancing research on neurological disorders. This initiative seeks to establish a repository that will maintain, derive, and distribute high-quality human fibroblast and induced pluripotent stem cell (iPSC) lines, ensuring rigorous quality assessment and broad accessibility to qualified researchers in academia and industry. The funding opportunity, with a total anticipated amount of $1.4 million for one award in fiscal year 2025, emphasizes the importance of expertise in stem cell technology and data management, with applications due by October 17, 2024. Interested applicants can find more information and contact NIH Grants Information at grantsinfo@nih.gov for inquiries.

    Point(s) of Contact
    Files
    Title
    Posted
    The National Institutes of Health (NIH) is inviting applications for funding opportunities under the NINDS Human Cell and Data Repository (NHCDR) aimed at supporting research on neurological disorders. This funding notice seeks to establish a repository that will maintain, derive, and distribute high-quality human fibroblast and induced pluripotent stem cell (iPSC) lines while adhering to rigorous quality assessment standards. The goals include producing and characterizing new iPSC lines, standardizing procedures, and ensuring broad distribution to qualified researchers in academia and industry. Key requirements for applicants include demonstrating expertise in stem cell technology, data management, and project oversight. Eligible entities range from higher education institutions to nonprofits and government agencies, with funding anticipated to total $1.4 million for one award in fiscal year 2025. The application process emphasizes the need for comprehensive data sharing and compliance with NIH protocols. Reviews will focus on the scientific merit of the project, including its significance and the applicant's capacity to effectively manage resources and deliver high-quality cell lines. This initiative represents a strategic effort by the NIH to enhance research capabilities in neurological disorders and foster collaborations across academic and industry sectors.
    Similar Opportunities
    Single Source: The NIGMS Human Genetic Cell Repository (U42 - Clinical Trial Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a non-competitive funding opportunity for a cooperative agreement to support the Human Genetic Cell Repository (HGCR), with a focus on maintaining and distributing a diverse collection of human cell lines and DNA samples for biomedical research. The initiative aims to enhance the repository's capacity by acquiring new cell lines from diverse populations, ensuring ethical practices in sample collection, and promoting inclusivity in research efforts. This funding opportunity provides up to $1.75 million annually for a five-year project period, with applications due by June 10, 2026. Interested applicants can find more information and contact NIH Grants Information at grantsinfo@nih.gov or visit the funding announcement at https://grants.nih.gov/grants/guide/pa-files/PAR-24-055.html.
    Development and Validation of Human Cellular Models for Alzheimer's Disease-Related Dementias (ADRD) (R01 - Clinical Trial Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity for the development and validation of human cellular models for Alzheimer's Disease-Related Dementias (ADRD) through the R01 Research Project Grant mechanism. This initiative aims to create novel and complex cellular models that accurately reflect the multifaceted pathologies and various cell types associated with ADRD, with a strong emphasis on validation against human data to ensure scientific rigor. The total funding commitment for this opportunity is anticipated to be up to $4.5 million for FY2025, with individual project budgets capped at $500,000 in direct costs annually for a maximum duration of five years. Interested applicants can find more details and guidelines in the full announcement available at NIH Grants, and inquiries can be directed to grantsinfo@nih.gov. The application deadline is October 21, 2024.
    BRAIN Initiative: Production and distribution facilities for brain cell type-specific access reagents (U24 Clinical Trial Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a funding opportunity under the BRAIN Initiative to establish Production and Distribution Facilities (PDFs) for brain cell type-specific access reagents. The initiative aims to enhance the production and dissemination of reagents, such as viral vectors and nucleic acid constructs, to facilitate collaborative research on brain function among various NIH components. This funding opportunity anticipates a total of $2.4 million annually for 2 to 4 awards, with a project period of up to 5 years, and applications must address key functions including interfacing with Research Resource for Design and Development projects, scaled-up production, broad dissemination of reagents, and coordination of data sharing. Interested applicants can find more information and submit inquiries via email at grantsinfo@nih.gov, with the application deadline set for July 1, 2026.
    Research Resource for Human Organs and Tissues (U42 Clinical Trial Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity titled "Research Resource for Human Organs and Tissues" through a cooperative agreement mechanism (U42), aimed at supporting a program that provides and facilitates the availability of human tissues and organs for biomedical research. The initiative seeks to enhance the procurement, preservation, and distribution of diverse biospecimens, both normal and diseased, to aid researchers in understanding various diseases and addressing public health priorities. Applicants must demonstrate a proven track record in managing a human tissue and organ research resource, with direct costs capped at $720,000 over a potential five-year project period. The application period opens on December 24, 2024, with a submission deadline of September 25, 2025. For further inquiries, interested parties can contact NIH Grants Information at grantsinfo@nih.gov.
    Access and Manipulation of Brain Cell Subtypes Implicated in Aging and AD/ADRD (R61/R33 Clinical Trial Not allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH), through the National Institute on Aging (NIA), has announced a funding opportunity titled "Access and Manipulation of Brain Cell Subtypes Implicated in Aging and AD/ADRD." This initiative invites applications that propose innovative strategies to target and manipulate specific brain cell subtypes associated with aging and neurodegenerative diseases, including Alzheimer's Disease and related dementias. The funding aims to support the development of advanced tools utilizing adeno-associated virus (AAV) capsid engineering and enhancer element identification, with a focus on mechanistic research rather than clinical trials. Up to $6 million is available for 6–8 awards, with applications due by October 8, 2024. For further inquiries, interested applicants can contact NIH Grants Information at grantsinfo@nih.gov or visit the opportunity's webpage at https://grants.nih.gov/grants/guide/rfa-files/RFA-AG-25-024.html.
    BRAIN Initiative: Scaled reagent resources for brain cell type-specific access across vertebrate species (U01 Clinical Trial Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity through the BRAIN Initiative aimed at scaling up brain cell type-specific molecular or genetic access reagents across vertebrate species. This initiative seeks to develop and validate viral, non-viral, transgenic, and gene regulatory element screening technologies to enhance neuroscience research and improve understanding of brain circuits, ultimately aiding in the treatment of brain disorders. The program anticipates a total funding of $14 million per year, with a maximum project period of five years, and encourages applications from a diverse range of eligible institutions, including historically black colleges, tribal colleges, and non-profit organizations. Interested applicants should submit their proposals by January 17, 2025, and can direct inquiries to grantsinfo@nih.gov for further information.
    BRAIN Initiative: Data Archives for the BRAIN Initiative (R24 Clinical Trial Optional)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a Notice of Funding Opportunity (NOFO) for the BRAIN Initiative, aimed at developing web-accessible data archives to capture, store, and curate data related to neuroscience research. The initiative seeks to enhance research efforts by establishing community resource data archives that adhere to high-quality data standards and improve accessibility for the research community. With an anticipated funding amount of $4 million, NIH plans to award 3-4 grants, each lasting up to five years, and applicants are required to submit a Plan for Enhancing Diverse Perspectives (PEDP) as part of their proposals. Interested parties can find more information and submit inquiries via email at grantsinfo@nih.gov, with applications due by June 24, 2026.
    Prospective Observational Comparative Effectiveness Research in Clinical Neurosciences (UG3/UH3 Clinical Trial Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity for prospective observational comparative effectiveness research (CER) in clinical neurosciences, specifically through the National Institute of Neurological Disorders and Stroke (NINDS). This initiative aims to encourage grant applications that investigate preventive strategies, diagnostic approaches, and various interventions, including drugs, devices, and therapies, that align with NINDS's mission. The funding mechanism follows a UG3/UH3 cooperative agreement structure, starting with a 2-year planning phase (UG3) that may transition into a 5-year observational study phase (UH3) upon meeting specific milestones. Interested applicants, including a diverse range of organizations, must submit their applications by May 7, 2025, and can find more information at the provided NIH link or contact the NIH OER Webmaster at OERWebmaster03@od.nih.gov for inquiries.
    BRAIN Initiative: Clinical Studies to Advance Next-Generation Devices for Recording and Modulation in the Human Central Nervous System (UH3 Clinical Trial Optional)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity under the BRAIN Initiative to support clinical studies aimed at advancing next-generation devices for recording and modulation within the human central nervous system (CNS). This initiative encourages proposals for early-stage clinical investigations, including first-in-human studies, that focus on treating CNS disorders and enhancing understanding of brain functions, particularly through Significant Risk studies requiring FDA Investigational Device Exemptions (IDEs) for chronic implants. The NIH plans to allocate approximately $10 million annually to fund 5 to 7 projects, emphasizing the importance of collaborations with device manufacturers through a public-private partnership program, and requires a Plan for Enhancing Diverse Perspectives as part of the application. Interested applicants can find more information and submit inquiries via grantsinfo@nih.gov, with the application deadline set for January 28, 2027.
    Engineering Next-Generation Human Nervous System Microphysiological Systems (R21 Clinical Trials Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity through the R21 grant mechanism to support the development of next-generation human cell-derived microphysiological systems (MPS) that accurately replicate the architectures and functions of the human nervous system. This initiative aims to encourage high-risk, high-reward exploratory research, particularly relevant for addressing complex nervous system disorders, and is open to a diverse range of eligible applicants, including educational institutions, non-profits, and governmental entities. The funding, capped at $275,000 over a two-year period, emphasizes collaboration among experts in neurobiology, engineering, and ethics, and applications must adhere to NIH data management and sharing policies. Interested parties can find more information and submit inquiries via grantsinfo@nih.gov, with the application deadline set for January 7, 2026.