The National Science Foundation (NSF) is offering a grant opportunity titled "Computer and Information Science and Engineering (CISE): Core Programs, Large Projects," aimed at supporting innovative research and education projects in computing, communications, and information science. Proposals are invited from eligible applicants, including non-profit organizations and institutions of higher education, to tackle ambitious fundamental research problems that span multiple CISE core programs, with an emphasis on collaborative efforts among teams of investigators. This funding opportunity is critical for advancing knowledge in the field and is expected to distribute approximately $20 million across six awards, with individual project budgets ranging from $3 million to $5 million over a duration of 3 to 5 years. Interested parties should submit their proposals by September 29, 2025, and can reach out to NSF grants.gov support at grantsgovsupport@nsf.gov for assistance.