The U.S. National Science Foundation (NSF) is offering a federal grant opportunity titled "Computer and Information Science and Engineering (CISE): Core Programs, Large Projects," aimed at supporting innovative research and education projects in computing, communications, and information science. Proposals are invited from eligible applicants, including non-profit organizations and accredited institutions of higher education, to tackle ambitious fundamental research problems that span multiple CISE core programs, with an emphasis on collaborative efforts among investigators with complementary expertise. The total estimated funding for this program is $20 million, with individual project budgets ranging from $3 million to $5 million over a duration of 3 to 5 years, and proposals must be submitted by the specified deadline. For further information, interested parties can contact NSF grants.gov support at grantsgovsupport@nsf.gov or visit the NSF publication page at http://www.nsf.gov/publications/pub_summ.jsp?ods_key=nsf24572.