The National Eye Institute (NEI) is inviting applications for its Collaborative Clinical Vision Research: Chair's Grant (UG1), aimed at supporting large-scale clinical trials encompassing screening, diagnosing, preventing, or treating vision disorders. This grant extends to various activities in vision health and requires compliance with stringent application protocols and deadlines, including the use of NIH's FORMS-H application packages starting January 2023. The grant is designed to provide substantial federal involvement in the proposed clinical trials, with detailed guidelines on application content, including a clinical protocol, milestone plans, and study organization. Eligible applicants span a wide range of organizations, including higher education institutions and nonprofits. The funding opportunity is set with specific timelines for submission, merit review, and award dates leading up to May 2026. Emphasizing the importance of diverse participation, the NEI encourages applications from underrepresented groups. The NIH conducts thorough evaluations of applications based on scientific merit, organizational capability, and the potential public health impact of the proposed research. Ultimately, this funding aims to foster advancements in vision science and improve outcomes for individuals affected by vision disorders.