Precision Approaches in Radiation Synthetic Combinations (PAIRS, R01 Clinical Trial Optional)
ID: 341117Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/341117

Additional Information

http://grants.nih.gov/grants/guide/pa-files/PAR-22-198.html
Timeline
    Description

    The National Institutes of Health (NIH) is inviting proposals for the Precision Approaches in Radiation Synthetic Combinations (PAIRS) program through the R01 grant mechanism, aimed at developing innovative cancer treatments by investigating synthetic vulnerabilities associated with tumor responses to radiation therapy. This funding opportunity encourages research that explores combined treatment strategies leveraging radiation modalities to enhance tumor-targeting precision, with a focus on pre-clinical studies or early-phase clinical trials. The initiative is critical for advancing precision oncology and improving health outcomes by addressing significant scientific barriers in cancer care. Interested applicants, including higher education institutions, nonprofits, and foreign entities, must submit their proposals by September 7, 2025, and can find additional information at the NIH grants website or contact the NIH OER Webmaster at OERWebmaster03@od.nih.gov for inquiries.

    Point(s) of Contact
    OERWebmaster03@od.nih.gov
    Files
    Title
    Posted
    PAR-22-198.html
    The National Cancer Institute (NCI) invites proposals for the Precision Approaches in Radiation Synthetic Combinations (PAIRS) program through the R01 grant mechanism. This initiative aims to develop innovative cancer treatments by exploring synthetic vulnerabilities linked to tumor responses from radiation therapy. Applicants can propose pre-clinical research or early-phase clinical trials to study and validate radiation-synthetic strategies, emphasizing tumor-targeting precision. Key aspects include the exploration of combined treatments that exploit cancer cell vulnerabilities created by radiation, utilizing various radiation modalities. Multi-Principal Investigator applications are encouraged to enhance collaborative efforts across disciplines. Eligible applicants range from higher education institutions to nonprofits and foreign entities, with applications due by specific deadlines based on the NIH schedule. Projects must adhere to the R01 guidelines, showing preliminary data supporting their hypotheses. The funding opportunity emphasizes the integration of novel approaches to optimize the therapeutic index of cancer treatments while addressing crucial scientific barriers. The program fosters advancements in precision oncology, seeking to transform cancer care through research that is responsive to the dynamics of radiation therapy in conjunction with targeted therapies. Overall, this FOA promotes innovative research to improve cancer treatments, aligning with the broader goals of enhancing health outcomes through precision medicine.
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