The United States Agency for International Development (USAID) is preparing to release a Notice of Funding Opportunity (NOFO) and Request for Information (RFI) for the Health Security Activity in Ethiopia, aimed at enhancing the country's capacity to combat infectious diseases. This initiative seeks feedback on a draft Activity Description and cost-sharing contributions, focusing on reducing morbidity and mortality through a One Health approach that integrates human, animal, and environmental health. The program is critical for improving Ethiopia's public health infrastructure, particularly in addressing rising zoonotic diseases and strengthening laboratory capabilities, with a total funding amount of $27 million and a deadline for responses set for March 28, 2024. Interested organizations can submit their feedback via email to Tesfaye Wolde at twolde@usaid.gov, with a copy to Deborah Rakowski at drakowski@usaid.gov.