The National Institutes of Health (NIH) has posted a grant opportunity titled "Early-Stage Development of Informatics Technologies for Cancer Research and Management (U01 Clinical Trial Optional)". This grant aims to advance cancer model systems that replicate human immunity in the tumor microenvironment to enhance the predictability of immuno-oncology studies. The proposed research projects should focus on recreating the human immune system in cancer models using human cells or tissues, either in vivo or in vitro. The goal is to achieve a level of representation of the human immune system that surpasses what can be achieved with murine models. Models that do not involve the introduction of human immune lineage cells will not be considered responsive. The funding instrument for this opportunity is a Cooperative Agreement, and there is no cost sharing or matching requirement. The grant has a maximum award ceiling of $300,000. Eligible applicants include various institutions and organizations, such as Alaska Native and Native Hawaiian Serving Institutions, Faith-based or Community-based Organizations, and U.S. Territories or Possessions. The closing date for applications is November 15, 2024. For more information and to apply, visit the following link: http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-24-017.html. For any inquiries, contact NIH Grants Information at grantsinfo@nih.gov.