The United States Agency for International Development (USAID) is seeking feedback through a Request for Information (RFI) for the anticipated Strengthening Local Health Security Activity in Vietnam, aiming to fortify the country's capacity to manage emerging infectious diseases over five years, with potential funding of up to $21.5 million. The initiative emphasizes a One Health approach to enhance prevention, detection, and response to epidemic-prone diseases at the subnational level. Interested organizations are invited to comment on the draft Program Description, focusing on objectives such as zoonotic disease prevention, surveillance enhancement, and improved risk communication. The context highlights Vietnam's vulnerability due to its high population density, agricultural practices, and limited coordination between animal and public health sectors. Proposed interventions include refining disease surveillance systems, strengthening community engagement, and improving sanitary practices across various animal health sectors. The RFI allows stakeholders to contribute insights while clarifying that it does not constitute a funding opportunity or application solicitation. Through this initiative, USAID aims to address critical health threats and foster community resilience against zoonotic diseases.