The USAID Strengthening Local Health Security Activity is a potential five-year award with a potential funding of up to $21.5 million. This activity aims to strengthen Vietnam's capacity at the subnational levels to effectively prevent, detect, and respond to epidemic-prone emerging infectious diseases through One Health approaches to achieve Global Health Security (GHS) targets. The purpose of this Request for Information (RFI) is to gather feedback from capable and interested organizations on the draft Program Description. USAID is seeking relevant feedback and comments to design the anticipated activity. This RFI is not a Notice of Funding Opportunity (NOFO) and does not commit the U.S. Government to issue any notice of funding opportunity or award an assistance agreement. Responses to this RFI are voluntary.