The USAID Counter Wildlife Trafficking Notice of Funding Opportunity (NOFO) issued on January 5, 2021, invites qualified entities to apply for a Cooperative Agreement aimed at combating wildlife trafficking in Vietnam. The anticipated award amount is up to $15 million over five years, focusing on enhancing government commitment, strengthening law enforcement, and reducing consumer demand for illegal wildlife products. With Vietnam being a significant hub for wildlife trafficking, especially for species like rhinos, elephants, and pangolins, this initiative aims to address serious ecological and health risks exacerbated by the illegal wildlife trade. Key objectives include engaging political champions, enhancing law enforcement coordination, and employing behavior change strategies for demand reduction. A primary focus will be on areas with high trafficking activities, including major cities and border points. The NOFO emphasizes the need for innovative solutions and collaboration with governmental and non-governmental entities, ensuring adaptability to changing contexts, particularly in the wake of the COVID-19 pandemic. The submission process requires potential applicants to adhere to specific guidelines and deadlines, with a strong emphasis on a partnership approach involving local stakeholders. The announcement serves as a strategic effort for Vietnam’s wildlife conservation and international collaboration against wildlife crime.