The National Institutes of Health (NIH) is offering a grant opportunity titled "Adolescent Overdose Prevention and SUD Treatment Initiative (R34 - Clinical Trial Optional)" aimed at developing effective interventions for overdose prevention and substance use disorder (SUD) treatment for adolescents aged 12-18. This initiative seeks pilot projects and preliminary research that focus on harm reduction, treatment effectiveness, and understanding patterns of substance use, particularly in light of rising adolescent overdose deaths. Eligible applicants include a wide range of organizations, such as higher education institutions and community-based organizations, with a direct cost limit of $450,000 for projects lasting up to three years. The application submission window opens on February 13, 2024, and interested parties can reach out to NIH Grants Information at grantsinfo@nih.gov for further inquiries. More details can be found in the full announcement at https://grants.nih.gov/grants/guide/rfa-files/RFA-DA-25-031.html.