NIH SIREN Neurologic Clinical Trials (UG3/UH3 - Clinical Trial Required)
ID: 357036Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Cooperative Agreement

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/357036

Additional Information

http://grants.nih.gov/grants/guide/pa-files/PAR-25-049.html
Timeline
    Description

    The National Institutes of Health (NIH) has announced a Notice of Funding Opportunity (NOFO) for the NIH SIREN Neurologic Clinical Trials (UG3/UH3 - Clinical Trial Required), aimed at supporting multi-center clinical trials focused on neurological emergencies such as status epilepticus and traumatic brain injury. This initiative encourages collaboration with the NIH SIREN Clinical Coordinating Center to ensure efficient trial implementation, while applicants are expected to provide rigorous preclinical data and compelling rationales for their proposed interventions. The funding opportunity operates under a phased mechanism, with UG3 for planning and UH3 for execution, reflecting a commitment to enhance clinical research in emergency care. Interested applicants can find more information and application guidelines at the provided link, with a submission deadline of March 6, 2026, and no cost-sharing or matching requirements.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    PAR-25-049.html
    The Department of Health and Human Services, through the National Institutes of Health (NIH), has issued a Notice of Funding Opportunity (NOFO) titled NIH SIREN Neurologic Clinical Trials (UG3/UH3 - Clinical Trial Required). This funding initiative encourages applications for multi-center clinical trials aimed at addressing neurological emergencies, such as status epilepticus and traumatic brain injury, under the Strategies to Innovate Emergency Care Clinical Trials Network (SIREN). Successful applicants will collaborate with the NIH SIREN Clinical Coordinating Center for efficient trial implementation while adhering to specific guidelines regarding application preparation and submission. The NOFO provides critical application timelines, eligibility criteria, and detailed information on project phases, promoting innovative trial designs and rigorous scientific standards. The funding opportunity operates under a phased mechanism (UG3 for planning stages and UH3 for execution), requiring evidence of rigorous preclinical data and compelling rationales for proposed interventions. The collaboration with NIH aims to consolidate expertise in emergency care, improving outcomes in neurological and cardiovascular emergencies. Overall, this NOFO reflects a significant commitment by federal agencies to enhance clinical research in emergency care by leveraging existing infrastructure and fostering collaborations across various institutions.
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