The National Institutes of Health (NIH) is inviting applications for the "Transformative Research to Address Health Disparities and Advance Health Equity" initiative, aimed at funding innovative research that addresses social determinants of health (SDOH) to significantly reduce health disparities and promote equity among underserved populations. This cooperative agreement seeks projects that demonstrate a compelling potential to produce major impacts on health equity, with a maximum funding amount of $500,000 per year for a project duration of up to five years, and a total funding commitment of approximately $3 million for 4-6 awards. Applications must include a Plan for Enhancing Diverse Perspectives (PEDP) and are expected to engage in community partnerships, with submission deadlines starting from January 29, 2025. For further inquiries, applicants can contact NIH Grants Information at grantsinfo@nih.gov or visit the opportunity announcement at https://grants.nih.gov/grants/guide/rfa-files/RFA-NR-25-003.html.