DOD Amyotrophic Lateral Sclerosis, Clinical Outcomes and Biomarkers Award
ID: 358720Type: Posted
Overview

Buyer

Dept. of the Army -- USAMRAA (DOD-AMRAA)

Eligible Applicants

Unrestricted

Funding Category

Science and Technology and other Research and Development

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/358720
Timeline
    Description

    The Department of the Army, through the US Army Medical Research and Development Command (USAMRAA), is inviting applications for the Amyotrophic Lateral Sclerosis Research Program (ALSRP) Clinical Outcomes and Biomarkers Award (COBA) for fiscal year 2025. This grant aims to support the development and validation of clinical outcomes and biomarkers specifically for enhancing clinical trials in Amyotrophic Lateral Sclerosis (ALS), focusing on targeted therapies or genetic mutations rather than broad applicability to all patients. With an estimated total program funding of $6.2 million, the program anticipates awarding approximately five grants, each with a maximum budget of $750,000 for a duration of up to three years. Interested applicants must submit a pre-application by June 6, 2025, followed by a full application due by August 27, 2025. For further inquiries, applicants can contact the CDMRP Help Desk at help@eBRAP.org or call 301-682-5507.

    Point(s) of Contact
    help@eBRAP.org
    Files
    Title
    Posted
    A03.pdf
    The Department of Defense's Amyotrophic Lateral Sclerosis Research Program (ALSRP) invites applications for the Clinical Outcomes and Biomarkers Award (COBA) for fiscal year 2025. This funding opportunity aims to support research focused on developing and validating clinical outcomes and biomarkers to enhance ALS clinical trials, targeting specific therapies or genetic mutations without needing broad applicability to all patients. Approximately $6.2 million is allocated to fund around five awards, with a maximum budget of $750,000 for a period of up to three years. Eligible applicants include both domestic and foreign organizations, academic institutions, and non-profit entities. Independent investigators at all career levels can serve as Principal Investigators. The application process includes a two-step submission: a pre-application due by June 6, 2025, and a full application due by August 27, 2025. Key focus areas include identifying clinical biomarkers for ALS and developing outcome measures that could impact clinical trial success. The proposal must incorporate community collaboration, emphasizing the involvement of patients and caregivers to ensure research relevance. Applications should detail plans for data sharing and resource utilization, aligning with regulatory considerations for ALS therapy development. The review process comprises preliminary screenings and comprehensive assessments evaluating scientific merit and relevance to the program’s objectives.
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