Development of Biomarkers or Composite Biomarkers for Neurological and Neuromuscular Disorders (R61/R33 - Clinical Trial Optional)
ID: 356874Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/356874

Additional Information

http://grants.nih.gov/grants/guide/pa-files/PAR-25-024.html
Timeline
    Description

    The National Institutes of Health (NIH) is inviting applications for the Development of Biomarkers or Composite Biomarkers for Neurological and Neuromuscular Disorders through a phased grant mechanism (R61/R33). This funding opportunity aims to enhance the discovery and early evaluation of candidate biomarkers that can facilitate the clinical development of neurotherapeutics and improve clinical care decisions. The initiative emphasizes the importance of multidisciplinary collaboration and requires applicants to validate biomarkers in a phased approach, with the R61 phase focusing on proof of concept studies and the R33 phase on preliminary clinical validation. Interested applicants should note that the application deadline is January 7, 2028, and they can direct inquiries to NIH Grants Information at grantsinfo@nih.gov. For further details, applicants can refer to the full announcement available at https://grants.nih.gov/grants/guide/pa-files/PAR-25-024.html.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    PAR-25-024.html
    The National Institutes of Health (NIH) invites applications for the Development of Biomarkers or Composite Biomarkers for Neurological and Neuromuscular Disorders under the phased award mechanism (R61/R33). This funding opportunity aims to enhance the development of candidate biomarkers that can improve the efficiency of clinical trials and clinical care decisions. Applicants are expected to validate biomarkers in a phased manner: the R61 phase focuses on proof of concept studies to confirm their potential, while the R33 phase conducts preliminary clinical validation concerning specific contexts of use. The application requires a detailed plan for enhancing diverse perspectives and the submission of pre-defined milestones for assessment. Key dates for submissions span from January 2025 to 2027, with budgets reflecting project needs and a total project duration of up to five years. The funding opportunity emphasizes multidisciplinary team collaboration and the importance of leveraging existing NIH resources. NIH seeks to support innovative biomarker research that addresses critical clinical needs within neurological disorders, thereby contributing to advancements in therapeutic development and healthcare quality.
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