The National Institutes of Health (NIH) is offering the Centers of Biomedical Research Excellence (COBRE) Phase 1 grant, aimed at enhancing biomedical research capacity in eligible institutions through the establishment of thematic, multi-disciplinary centers. This initiative seeks to strengthen the research infrastructure and support junior investigators in competing for independent funding, particularly in states with historically low NIH grant success rates. The program emphasizes collaboration, mentoring, and infrastructure improvements in specific biomedical research areas aligned with institutional priorities. Interested applicants, including state governments and various minority-serving institutions, can apply for grants with an award ceiling of $1.5 million, with applications due by January 30, 2025. For further inquiries, contact NIH Grants Information at grantsinfo@nih.gov or visit the additional information link at http://grants.nih.gov/grants/guide/pa-files/PAR-22-250.html.