Botanical Dietary Supplements Translational Research Teams (RM1 Clinical Trial Required)

Active
Yes
Status
Posted
Published Date
March 14th, 2024
Close Date
July 8th, 2024
Award Ceiling
$1,500,000.00
Opportunity No.
RFA-OD-24-014

Agency

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Summary

The National Institutes of Health (NIH) has posted a grant opportunity titled "Botanical Dietary Supplements Translational Research Teams (RM1 Clinical Trial Required)". This grant aims to support collaborative and translational research projects focused on chemically complex botanical and other natural products relevant to dietary supplements. The goal is to conduct highly informative clinical trials to measure the effects of these products on quantitative, objective measures of human resilience. The grant seeks to foster dynamic and synergistic interactions among experts from various disciplines to ensure rigor in all aspects of the research. The projects will be carried out by multi-PD/PI teams working on integrated specific aims. The research outcomes will include optimal parameters for a future proposed clinical efficacy trial, as well as the development and validation of critical knowledge and methods for interpreting such a trial. The grant also emphasizes the importance of enhancing workforce and institutional capacity to conduct rigorous, transdisciplinary research on chemically complex natural products. The ultimate aim is to provide a strong foundation for a future highly informative clinical efficacy trial on the effects of resilience using a chemically complex natural product. This grant opportunity is part of the Consortium Advancing Research on Botanicals and Other Natural Products (CARBON) Program. Other components of the program include RFA-AT-24-008, which focuses on leveraging data at scale to understand natural product impacts on whole person health (R01), and RFA-AT-24-007, which is a limited competition for a research resource on natural product nuclear magnetic resonance data (R24). The deadline for applications is July 8, 2024. The maximum award ceiling is $1,500,000. Eligible applicants include Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), eligible agencies of the Federal Government, faith-based or community-based organizations, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Indian/Native American Tribal Governments, non-domestic (non-U.S.) entities (foreign organizations), regional organizations, Tribally Controlled Colleges and Universities (TCCUs), and U.S. territories or possessions. For more information and to apply, please visit the following link: Botanical Dietary Supplements Translational Research Teams (RM1 Clinical Trial Required). If you have any inquiries, you can contact NIH Grants Information at grantsinfo@nih.gov.

Description

The purpose of this Notice of Funding Opportunity (NOFO) is to support collaborative, transdisciplinary, translational research projects which advance exceptionally promising, chemically complex botanical and other natural products relevant to dietary supplements towards highly informative clinical trials of their effects on quantitative, objective measures of human resilience. Dynamic, synergistic interactions among the range of experts required to ensure rigor in all aspects of this research will be supported by a multi-PD/PI team collaborating on a single set of integrated specific aims, culminating in data on optimal parameters for a future proposed clinical efficacy trial, as well as the development and validation of other critical knowledge and methods for interpretation of such a trial, such as clinical assessment of the engagement of an outcome-relevant target. Enhancing workforce and institutional capacity to conduct future rigorous, transdisciplinary research on chemically complex natural products must be built into the plans for research and for enhancing diverse perspectives. Achievement of the RM1 specific aims is expected to provide a strong foundation for a future highly informative clinical efficacy trial of the effects on resilience of a chemically complex natural product. This NOFO is one component of the Consortium Advancing Research on Botanicals and Other Natural Products (CARBON) Program. Other components of this Program include RFA-AT-24-008, Leveraging Data at Scale to Understand Natural Product Impacts on Whole Person Health (R01) and RFA-AT-24-007, Limited Competition: Research Resource for Natural Product Nuclear Magnetic Resonance Data (R24).

Contact Information

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Opportunity Lifecycle

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