The National Institutes of Health (NIH) is inviting applications for the Complex Integrated Multi-Component Projects in Aging Research (U19 Clinical Trial Optional) program, aimed at supporting large-scale research initiatives that address critical questions related to aging. This funding opportunity encourages multidisciplinary collaboration among higher education institutions, nonprofits, and government entities, focusing on projects that integrate various components such as coordinating centers and clinical sites, particularly in areas like Alzheimer’s disease and health disparities. There is no limit on application budgets, but they must accurately reflect project needs, with a maximum project period of five years. Interested applicants should note that the submission deadline for the first round is January 25, 2023, and can find further details and application instructions at the provided NIH link or by contacting the NIH OER Webmaster at OERWebmaster03@od.nih.gov.