The Department of Defense, through the Army Medical Research Acquisition Activity, is seeking to award a sole source contract to Potomac Affinity Proteins, LLC for the development and testing of a protease cascade designed to detect protein targets in environmental samples. This innovative research requirement involves the use of target-specific antibodies or related ligands to aggregate protein targets and initiate a signal cascade, which is critical for advancing biotechnology applications in health and safety. The contract will be awarded without further competition unless other capable sources respond by the deadline of 12:00 PM EST on May 6, 2025, with evidence of their ability to meet the requirements. Interested parties should direct their inquiries to Tara Borntreger at tara.j.borntreger.civ@health.mil or Jayme Fletcher at jayme.l.fletcher2.civ@health.mil.