The Sources Sought Notice RFP #75N93025R00014, issued by the NIH, seeks small business contractors capable of conducting clinical studies focused on infectious agents, vaccines, and antivirals for both adult and pediatric populations. The aim is to assess safety, immunogenicity, and efficacy of vaccines against various viruses, including emerging threats like Zika. This effort builds on decades of NIH-led research and develops candidates that have progressed towards licensing agreements across multiple countries. The project involves three task areas: evaluating vaccine safety and immunogenicity in children and adults and conducting challenge studies in an inpatient setting. The anticipated contract duration is seven years, from August 2026 to August 2033, structured as a cost-reimbursement IDIQ contract. Responses to this notice should include the capability statement, detailing prior experience, professional qualifications, and the ability to execute the tasks required. Businesses must provide specific details such as UEI number, company information, and confirm registration with SAM. The government emphasizes the voluntary nature of submissions, which will not obligate any contract award. This initiative highlights the NIH's ongoing commitment to advancing medical research through strategic partnerships with capable small businesses.