The Department of Health and Human Services, through the National Institutes of Health (NIH) and specifically the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), is announcing its intent to negotiate a sole-source contract with Jackson Laboratory for the establishment and maintenance of a Repository of Mouse Models for Down Syndrome. This initiative aims to produce, acquire, maintain, and distribute genetically characterized mouse models, particularly focusing on the Ts65Dn strain, to support cytogenetic research related to Down syndrome. The contractor will also be responsible for essential tasks such as cryopreservation, pathogen testing, and phenotypic characterization, with ongoing consultations with a Scientific Advisory Board to align with the research community's needs. Interested parties are encouraged to submit capability statements by the specified deadline, as this contract is anticipated for one year with options for four additional periods, and is not currently open for competitive proposals. For further inquiries, contact Dana L. Harris at harrisd@mail.nih.gov or +1 301 443 7798.