A--Repository of Mouse Models for Down Syndrome
ID: 75N94025R00007Type: Presolicitation
Overview

Buyer

HEALTH AND HUMAN SERVICES, DEPARTMENT OFNATIONAL INSTITUTES OF HEALTHNATIONAL INSTITUTES OF HEALTH NICHDBETHESDA, MD, 20817, USA

NAICS

Research and Development in Biotechnology (except Nanobiotechnology) (541714)

PSC

HEALTH R&D SERVICES; HEALTH CARE SERVICES; APPLIED RESEARCH (AN12)

Original Source

https://sam.gov/opp/d7bd482adef64e2e80b99d1d363a732d/view
Timeline
    Description

    The Department of Health and Human Services, specifically the National Institutes of Health (NIH) through the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), is seeking proposals for a contract to establish and maintain a repository of mouse models for Down syndrome, focusing on human trisomy for chromosome 21. The contractor will be responsible for producing, acquiring, maintaining, and distributing these specialized mouse models, which are critical for cytogenetic research and understanding Down syndrome. The contract period is set from September 22, 2025, to September 21, 2026, with proposals due by July 11, 2025, at 4:30 PM EST. Interested parties can contact Dana L. Harris at harrisd@nih.gov or call +1 301 443 7798 for further information.

    Point(s) of Contact
    HARRIS, DANA L
    +1 301 443 7798
    harrisd@mail.nih.gov
    Files
    Title
    Posted
    Pre-Sol_15-day_notice_Repository_of_Mouse_Models_-_4_3_2025_FINAL_1.pdf
    The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) is announcing its intent to negotiate a sole-source contract with Jackson Laboratory for the establishment and maintenance of a Repository of Mouse Models for Down Syndrome. This initiative aims to supply the Down syndrome research community with genetically characterized mouse models, specifically maintaining and breeding the established Ts65Dn strain and potentially new strains as they become available. The contractor will also be responsible for cryopreservation procedures, pathogen testing, and phenotypic characterization of the mice. Regular consultations will be held with a Scientific Advisory Board to ensure meeting the community's research needs. The contract is anticipated for one year with the option for four additional periods and is not currently a request for competitive proposals. Interested parties are invited to submit capability statements by a specified deadline. The focus of this notice is to communicate the government's intent to source specialized mouse model services with a unique capability offered solely by Jackson Laboratory, reflecting the needs of the Down syndrome research field.
    Pre-Sol_15-day_notice_Repository_of_Mouse_Models_-_4_3_2025_FINAL.pdf
    The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)/NIH intends to award a sole-source contract to Jackson Laboratory (JAX) for maintaining a "Repository of Mouse Models for Down Syndrome." JAX is the only known source for the necessary mouse strains, particularly the Ts65Dn model, which are difficult to breed and maintain. The contractor will be responsible for breeding various Down syndrome mouse strains, acquiring new strains in consultation with NICHD, convening a Scientific Advisory Board, cryopreserving embryos, distributing models to approved investigators, testing animals for pathogens, characterizing phenotypes, and publicizing model availability. Regular communication with NICHD is required to monitor progress and address issues. The anticipated contract period is one year with four potential option periods. Other qualified firms must submit a detailed capability statement by April 18, 2025, to be considered.
    RFP_75N94025R00007-Amendment_1_6-18-2025_FINAL_signed_0001.pdf
    Amendment 001 to RFP 75N94025R00007, issued by the National Institutes of Health (NIH) through the Eunice Kennedy Shriver National Institute of Child Health and Human Development, modifies the Request for Proposal for a “Repository of Mouse Models for Down Syndrome.” The key change is the complete removal of Section III. Technical Specifications – C. Repository Maintenance, Breeding and Distribution 5.e. This deleted section detailed specific quarterly reporting requirements for the distribution of mice, including comprehensive information about investigators, shipments, research projects, funding sources, and publication details, all to be maintained within an existing Laboratory Information Management System (LIMS). The amendment clarifies that all other terms and conditions of the original RFP, with a due date of July 11, 2025, 4:30 PM Local Time (EST), remain unchanged. The Jackson Laboratory is identified as the contractor related to this RFP.
    RFP-75N94025R00007_Mouse_Models_JAX_Release_2.pdf
    The National Institutes of Health (NIH) has issued Request for Proposal (RFP) Number 75N94025R00007 for the establishment of a "Repository of Mouse Models for Down Syndrome." This RFP, issued on May 27, 2025, seeks a contractor to produce, maintain, and distribute aneuploid mice, specifically focusing on models of human trisomy for chromosome 21. Proposals are due by 4:30 PM EST on July 11, 2025. The selected contractor must be registered with the System for Award Management (SAM) and adhere to strict reporting requirements, including technical progress reports (monthly, quarterly, and final), financial conflict of interest disclosures, and invention reporting. The contract emphasizes compliance with NIH policies on reproducibility, public access to research, animal welfare, and data sharing, with specific prohibitions on certain uses of funds (e.g., promoting controlled substance legalization, pornography, gun control, or promotional items). The period of performance is from September 22, 2025, to September 21, 2026. Key personnel are considered essential, and any changes require Contracting Officer approval. Invoices must be submitted electronically via the Department of Treasury's Invoice Processing Platform (IPP).
    Sol_75N94025R00007_Amd_0001.pdf
    Amendment 001 to Solicitation 75N94025R00007, issued by the National Institute of Child Health (NICHD) in Bethesda, MD, modifies the original Request for Proposal (RFP). The primary purpose of this amendment is to remove Section III. Technical Specifications – C. Repository Maintenance, Breeding and Distribution 5.e. in its entirety from the RFP. The due date for offers remains unchanged at July 11, 2025, 4:30 PM Local Time (Eastern Standard Time (EST)). Offerors must acknowledge receipt of this amendment by completing and returning copies of the amendment, acknowledging receipt on their submitted offer, or by separate communication referencing the solicitation and amendment numbers. Failure to acknowledge receipt prior to the specified deadline may result in the rejection of the offer.
    Sol_75N94025R00007.pdf
    This government Request for Proposal (RFP) from the National Institutes of Health (NIH), National Institute of Child Health and Human Development (NICHD), solicits proposals for a contract to establish and maintain a repository of aneuploid mice, primarily models of human trisomy for chromosome 21 (Down Syndrome). The contract will cover producing, maintaining, and distributing these mouse models. Key aspects include detailed reporting requirements (monthly, quarterly, and final technical progress reports, dual-use research, financial conflict of interest, and invention reports), strict adherence to animal welfare policies, data sharing protocols, and restrictions on the use of funds for promotional items or certain advocacy activities. The solicitation outlines administrative data, invoicing procedures, and incorporates various Federal Acquisition Regulation (FAR) and HHS Acquisition Regulation (HHSAR) clauses related to safeguarding information, telecommunications, responsibility matters, and other contractual obligations. The period of performance is from September 22, 2025, to September 21, 2026.
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