The Department of Defense, through the Joint Program Executive Office for Chemical, Biological, Radiological, and Nuclear Defense (JPEO-CBRND), is issuing a Request for Information (RFI) focused on innovations in biologics manufacturing. This RFI seeks information on capabilities and technologies related to biologics manufacturing, specifically targeting cell-free production capabilities, advancements in process control, and methods to expedite drug substance release. The initiative aims to enhance medical solutions for crisis response and improve preparedness against future threats. Interested parties are encouraged to share their capabilities via the Joint Enterprise Technology Tool (JETT) platform, with no commitment from the government to issue a subsequent Request for Proposal (RFP).