The Department of Health and Human Services, specifically the National Institutes of Health (NIH), is seeking innovative proposals for the development of In Vivo Non-Invasive Optical Imaging Approaches for Biological Systems. The initiative aims to address the challenges posed by light scattering in biological tissues, which currently limits the effectiveness of non-invasive optical imaging techniques in assessing tissue function and structure. This funding opportunity encourages the advancement of next-generation imaging technologies that can achieve deeper penetration and higher resolution in biological systems. Interested applicants should note that the application due date is March 7, 2025, by 5:00 PM local time, and are encouraged to submit a letter of intent by the same date. For further inquiries, contact Jonathan Pollock at jpollock@mail.nih.gov or Robert Bailey at rob.bailey@nih.gov.