National Cancer Institute (NCI) Small Business Innovation Research (SBIR) Innovative Concept Award Program - Fiscal Year 2026
ID: 75N91025R00005 Type: Solicitation
Overview

Buyer

HEALTH AND HUMAN SERVICES, DEPARTMENT OFNATIONAL INSTITUTES OF HEALTHNIH NCIBethesda, MD, 20892, USA

NAICS

Research and Development in the Physical, Engineering, and Life Sciences (54171)

PSC

HEALTH R&D SERVICES; HEALTH CARE SERVICES; APPLIED RESEARCH (AN12)

Set Aside

Total Small Business Set-Aside (FAR 19.5) (SBA)

Original Source

https://sam.gov/opp/75237c3988b24edbbbfc9751ef7eba7f/view
Timeline
    Description

    The National Cancer Institute (NCI) within the Department of Health and Human Services is soliciting proposals for the Small Business Innovation Research (SBIR) Innovative Concept Award Program for Fiscal Year 2026. This program aims to support small businesses in developing transformative technologies for the treatment and prevention of pediatric and rare cancers, particularly those with a 5-year survival rate below 50%. Proposals must demonstrate technical feasibility and include a clear development path, addressing specific clinical problems and cancer types, while also enhancing entrepreneurship skills and commercialization strategies. Interested applicants should submit preliminary white papers by June 4, 2025, with full proposals due by September 26, 2025. The initial funding amount for the Concept Award is $300,000, and applicants can contact Tanya Renwick at ncioasbir@mail.nih.gov for further information.

    Point(s) of Contact
    Tanya Renwick
    ncioasbir@mail.nih.gov
    Files
    Title
    Posted
    FY25 Presolicitation Notice.pdf
    The document contains a range of federal and state documents related to Requests for Proposals (RFPs) and grants, primarily focusing on funding opportunities and guidelines for various projects. It highlights the government's commitment to facilitating procurement processes for necessary services, products, and infrastructure enhancements that meet the needs of public agencies. Key topics include the eligibility criteria for applicants, application procedures, funding thresholds, timeline expectations, and compliance requirements with federal and local regulations. The structure suggests templates for proposals, detailing what information is necessary for consideration, including project goals, budgets, and qualifications of the applicants. These RFPs are essential mechanisms for ensuring transparency, equity, and accountability in government spending. The main purpose of these documents is to invite bids for specific projects while ensuring that all potential contractors are aware of the required standards and expectations. This is helpful for organizations seeking federal assistance or those wanting to contribute to government projects, therefore supporting economic development and public service improvements.
    FY26 SBIR Concept Solicitation.pdf
    The National Cancer Institute (NCI) is seeking proposals from small businesses for the Small Business Innovation Research (SBIR) Innovative Concept Award Program. This program aims to support research and development efforts focused on high-risk, transformative technologies for pediatric and rare cancers with a 5-year survival rate below 50%. Proposals are due by September 26, 2025, with preliminary white papers required by June 4, 2025. Notably, proposals must include a new requirement on the disclosure of foreign relationships. Participants are encouraged to engage in the I-Corps™ program, designed to facilitate commercialization of innovations derived from federal R&D. The funding consists of an initial Concept Award of $300,000 and subsequent phases leading to product commercialization. Eligibility is limited to small businesses fulfilling specific ownership and operational criteria, with a significant emphasis on performing R&D in the U.S. Applicants must also adhere to the SBIR/STTR policies and comply with established regulations governing human subjects and animal welfare. The program is part of a broader initiative to foster technological innovation in the private sector while expanding the role of small businesses in addressing federal research objectives.
    Similar Opportunities
    Support for Evaluating and Conducting Computational and Alternative Toxicological Methods for the National Institute of Environmental Health Sciences
    Health And Human Services, Department Of
    The Department of Health and Human Services, specifically the National Institute of Environmental Health Sciences (NIEHS), is seeking proposals from small businesses to support the evaluation and conduct of computational and alternative toxicological methods. The objective of this procurement is to assist NIEHS in chemical hazard and risk assessment while minimizing the use of animal testing, focusing on areas such as population variability, developmental neurotoxicity, and carcinogenicity. This contract, which is a Cost-Plus-Fixed-Fee type, has a base period of performance from June 1, 2026, to May 31, 2027, with nine additional one-year options and a potential six-month extension. Proposals are due by December 19, 2025, and must be submitted electronically via the NIH eCPS website; interested parties can contact Jason Williams at jason.williams2@nih.gov or Lisa Schaupp at lisa.schaupp@nih.gov for further information.
    FY26 FDA Broad Agency Announcement (BAA) for Advanced Research and Development of Regulatory Science
    Health And Human Services, Department Of
    The Department of Health and Human Services, specifically the Food and Drug Administration (FDA), is soliciting proposals through the FY26 Broad Agency Announcement (BAA) for advanced research and development in regulatory science. This opportunity aims to acquire basic and applied research that supports regulatory science and innovation, focusing on areas such as New Approach Methodologies, Advanced Manufacturing, and Clinical Outcome Assessments, among others. The FDA's initiative is crucial for enhancing scientific knowledge that aids in protecting and promoting public health, particularly for underrepresented populations and in reducing animal testing. Interested parties, including small businesses and academic institutions, are encouraged to submit proposals by February 24, 2026, and can reach out to Ian Weiss at Ian.Weiss@fda.hhs.gov or by phone at 301-796-5728 for further information.
    The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Seeks Industry Partners for Clinical Research Collaborations on Therapeutics, Diagnostics or Devices for Childhood Cholestatic Liver Diseases
    Health And Human Services, Department Of
    The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is seeking industry partners for clinical research collaborations focused on therapeutics, diagnostics, or devices for childhood cholestatic liver diseases. The initiative aims to engage collaborators in providing novel therapeutic agents and diagnostic tools for use in NIH-sponsored multi-center clinical trials targeting conditions such as biliary atresia and alpha-one antitrypsin deficiency, among others. This collaboration is critical for advancing research and improving clinical outcomes for children suffering from these rare liver diseases. Interested organizations must submit a Capability Statement detailing their proposed solutions and capabilities, with no funding provided by NIDDK for this opportunity. For inquiries, contact Edward Doo at dooe@niddk.nih.gov or Katrina Loh at katrina.loh@nih.gov.
    Biospecimen Core Resource
    Health And Human Services, Department Of
    The Department of Health and Human Services, specifically the National Institutes of Health (NIH) under the National Cancer Institute (NCI), is seeking to establish a Biospecimen Core Resource (BCR) to support various biospecimen-related activities. The BCR will operate under documented Standard Operating Procedures (SOPs) to facilitate the collection, processing, distribution, and storage of biospecimens as outlined in NCI Task Orders. This initiative is crucial for advancing cancer research and ensuring the integrity and availability of biospecimens for scientific studies. Interested parties can reach out to Apisit Viriya at apisit.viriya@nih.gov or Mataya Robinson at mataya.robinson@nih.gov for further details regarding this opportunity.
    Scalable Solutions Office (SSO) Mission Office Innovative Solutions Opening (ISO)
    Health And Human Services, Department Of
    The Department of Health and Human Services, through the Advanced Research Projects Agency for Health (ARPA-H), is soliciting proposals for the Innovative Solutions Opening (ISO) under the Scalable Solutions Office (SSO). This initiative aims to develop innovative solutions that enhance healthcare access, affordability, and distribution, particularly in underserved communities, while addressing challenges in biomanufacturing and health technology distribution. The solicitation is open until March 5, 2029, and encourages submissions from academia, non-profits, and for-profit entities, with multiple awards anticipated as Other Transactions. Interested parties must submit a Solution Summary for initial feedback before proceeding with a full proposal, adhering to strict guidelines on intellectual property, research security, and cost proposal requirements. For further details, proposers can reach out through the designated submission portals and must ensure compliance with the updated administrative and national policy requirements outlined in the solicitation documents.
    Inflammatory and Vascular Diseases Scientific Support
    Health And Human Services, Department Of
    The Department of Health and Human Services, specifically the National Institutes of Health (NIH), is seeking to award a contract for Inflammatory and Vascular Diseases Scientific Support to Exonova Biosciences. The procurement aims to secure the services of a highly qualified scientist with extensive expertise in immunology and hereditary autoinflammatory diseases, who will contribute to the NIH's Biomedical and Metabolic Imaging Branch's research initiatives. This contract is crucial for advancing understanding in the fields of inflammation and vascular biology, particularly in relation to metabolic disorders, and is set to commence on January 1, 2026, with a performance period extending through December 31, 2026. Interested parties must respond by December 15, 2025, and can direct inquiries to Kimesha Leake at Kimesha.leake@nih.gov.
    Treating Hereditary Rare Diseases With In Vivo Precision Genetic Medicines (THRIVE)
    Health And Human Services, Department Of
    The Department of Health and Human Services, through the Advanced Research Projects Agency for Health (ARPA-H), is soliciting proposals for the "Treating Hereditary Rare Diseases With In Vivo Precision Genetic Medicines (THRIVE)" program. This initiative aims to accelerate the development of innovative precision genetic medicines (PGMs) to treat hereditary rare diseases, focusing on creating integrated platforms that address technical and real-world challenges in genetic medicine. Proposals must include a solution summary, a PowerPoint presentation, and a detailed Gantt chart, with key deadlines set for October 31, 2025, for solution summaries and December 22, 2025, for PowerPoint submissions. Interested parties can contact the THRIVE Program at THRIVE@arpa-h.gov for further information.
    GENETIC MEDICINES AND INDIVIDUALIZED MANUFACTURING FOR EVERYONE (GIVE)
    Health And Human Services, Department Of
    The Department of Health and Human Services, through the Advanced Research Projects Agency for Health (ARPA-H), is soliciting proposals for the Genetic Medicines and Individualized Manufacturing for Everyone (GIVE) program. This initiative aims to revolutionize the biomanufacturing of RNA-based genetic medicines by fostering innovations in automated RNA manufacturing and integrated quality control, ultimately enabling rapid, cost-effective, and localized production in non-GMP environments. Interested parties must submit solution summaries by December 19, 2025, with full proposals due by February 27, 2026, and are encouraged to participate in a Proposers’ Day on November 13, 2025, for further insights. For additional information, please refer to the program's website or contact the designated email address.
    Access to and Use of the CB Insights Platform
    National Science Foundation
    The National Science Foundation (NSF) is seeking to award a sole source contract to CB Information Services, Inc. for access to the CB Insights Platform, which provides critical research and analytics data on global venture capital and mergers and acquisitions. The platform must include features such as round-by-round deal data, a focus on the cleantech sector, direct data feed or API functionality, and detailed financial and investor contact information. This procurement is essential for enhancing the NSF's capabilities in analyzing market trends and investment opportunities, with a total contract value of $60,000. Interested parties can reach out to Bethany Stutler at bstutler@nsf.gov, with responses due by December 15, 2025, and the contract award anticipated on December 19, 2025.
    NCI OA Special Notice of Subcontract Opportunity at the Frederick National Laboratory for Cancer Research
    Health And Human Services, Department Of
    The National Institutes of Health (NIH), through the National Cancer Institute (NCI), is seeking information regarding an Electronic Document Management System (EDMS) for the Frederick National Laboratory for Cancer Research (FNLCR), which is operated by Leidos Biomedical Research, Inc. The EDMS aims to centralize and enhance the control and maintenance of construction project documentation for the Facilities, Maintenance, and Engineering (FME) Directorate, thereby improving collaboration among project teams and facilitating reporting for lessons learned and metrics. This initiative is crucial for streamlining documentation processes and may expand to other directorates in the future. Interested parties should submit their responses by January 9, 2026, and direct any inquiries to Cody Wenner at cody.wenner@nih.gov.