The Advanced Research Projects Agency for Health (ARPA-H) is soliciting innovative research proposals through its Proactive Health Office (PHO) under solicitation number ARPA-H-SOL-24-106. The initiative focuses on enhancing health outcomes by developing solutions that prioritize disease prevention and early intervention, departing from traditional reactive healthcare approaches. Key interest areas include scalable disease detection methods, preventive treatments, and systems that promote wellness behaviors at a population level. Eligible proposers encompass universities, non-profits, small and large businesses, with an emphasis on projects that tackle significant health challenges or offer novel technologies. Proposal submissions must begin with a mandatory solution summary to gauge alignment with ARPA-H’s objectives. A thorough review process based on scientific merit and relevance will determine award-winning proposals, which could be funded through Other Transactions or Cooperative Agreements. The solicitation, open until March 2029, encourages innovative, interdisciplinary approaches and welcomes submissions from diverse entities while emphasizing compliance with federal regulations regarding human and animal research. This RFP represents a significant opportunity for entities capable of delivering transformative health solutions aligned with national health goals.

The document serves as an amendment to the ARPA-H-SOL-24-104, providing a template for submitting solution summaries for federally funded projects. It outlines required components, including a cover letter, concept summary, innovation and impact assessment, proposed work details, team organization, and a basis of estimate for funding. Submissions must be concise, adhering to formatting guidelines, and not exceeding six pages. The concept summary should clearly articulate how the proposed solution addresses specific HSF interest areas, emphasizing innovative and potentially disruptive technologies. Detail on outcomes, project deliverables, key milestones, and technical methodologies is essential, along with identification of adoption challenges and mitigation strategies for technical risks. Furthermore, the document emphasizes transparency in the financial component— detailing both the requested funds and project costs, which must encompass labor, materials, travel, and other direct expenses. The roles and qualifications of the project team members are also highlighted, ensuring clarity regarding responsibilities and expertise. This amendment establishes a structured approach for government RFP submissions, focusing on innovation, impact, and practical implementation while promoting compliance with federal funding requirements.