Solicitation from the Department of Health and Human Services, National Institutes of Health, seeks innovative solutions for the Proactive Health Office (PHO). The PHO aims to improve the healthspan and health outcomes of Americans before the onset of disease and diminished quality of life. The PHO is specifically interested in population-level improvements in disease prevention and wellness-promoting behaviors, as well as the development of early-detection methods and prophylactic interventions. System level innovations for effective delivery of proactive health are also sought. Solution summaries, questions, and proposal submissions should be made through the ARPA-H website.