The Department of Health and Human Services, specifically the National Institutes of Health, is seeking proposals for the development of therapies and technologies directed at enhanced pain management through the Small Business Technology Transfer (STTR) program. The focus of this solicitation is on improving pain measurement and treatment. The goal is to address the national opioid public health crisis by providing alternative treatment options for chronic pain, which affects over 25 million Americans. The research objectives include the development of tools and technologies to understand the biological underpinnings of chronic pain, the discovery and pre-clinical development of non-addictive analgesic treatments, and the advancement of new pain treatments through the clinical pipeline. The solicitation is open to various fields, including biology, medicine, engineering, and technology. The project duration can vary, and the funding specifics can be found on the grants.gov website. The open date for submissions is December 4, 2022, and the close date is April 5, 2025. For more information and to access the solicitation, visit the provided links.