The Department of Health and Human Services, specifically the National Institutes of Health, is seeking proposals for the development of therapies and technologies directed at enhanced pain management through the Small Business Innovation Research (SBIR) program. The focus of this solicitation is on improving pain measurement and treatment. The goal is to address the national opioid public health crisis by providing scientific solutions for chronic pain, which affects over 25 million Americans. The research objectives include enhancing pain management through the development of new screening tools, models, and therapies, as well as advancing non-addictive pain analgesic treatments and improving pain management strategies for acute and chronic pain conditions. The solicitation is open for applications until April 5, 2025, and interested applicants can find more information on the grants.gov website.