The Department of Health and Human Services, specifically the National Institutes of Health, is seeking proposals for the HEAL Commercialization Readiness Pilot (CRP) Program: Embedded Entrepreneurs for Small Businesses in Pain Management. This program aims to support the commercialization of Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Phase II or Phase IIb pain management technologies funded by the HEAL Initiative. The goal is to add experienced entrepreneurs to small business leadership teams and provide support for private fundraising and partnership activities. The program is part of the NIH HEAL Initiative, which aims to address the national opioid crisis. The FOA prioritizes applicants who demonstrate a need for private partnership to achieve commercialization and have not previously garnered significant private funding. The funding opportunity supports the addition of an expert in entrepreneurship and business development to small business leadership teams, as well as the development of a partnering plan to attract private funding. The proposed hire is expected to have executive-level positions such as Chief Business Officer or Chief Finance Officer and contribute at least 50% effort to the company. The funding can support labor costs associated with private partnering activities, and small businesses are expected to contribute to the compensation of the hired individual. Applicants should actively seek private funding or partnering and demonstrate readiness for fundraising activities. The proposed activities should be directly related to private fundraising and partnering, such as US-based travel to meet potential partners, legal activities, and business development activities. Applicants are expected to meet with a minimum of ten potential partners fitting the appropriate target profile for the technology and company.